Ezweni elikhula njalo lama-phytochemicals, i-berberine HCL igqama njenge-molecule ethakazelisayo. Ithathwe ohlotsheni lwezitshalo, okuhlanganisa i-goldenseal, i-Oregon grape, ne-barberry, i-berberine HCL ibilokhu igxile ezifundweni eziningi zesayensi ngenxa yemisebenzi yayo ehlukahlukene yebhayoloji.

I-Berberine HCL, noma usawoti we-hydrochloride we-berberine, i-pigment ephuzi enezinhlobonhlobo zezinhlelo zokwelapha ezingase zibe khona. Yaziwa ngezindawo zayo zokulwa nokuvuvukala, i-anti-microbial, kanye ne-anti-diabetic, phakathi kokunye. Ngaphezu kwalokho, i-berberine HCL ibonise isithembiso ekwelapheni izifo ezihlukahlukene, kuhlanganise ne-Hepatitis B no-C, i-ulcerative colitis, nesifo sikashukela.

Izakhiwo ze-antimicrobial ze-berberine HCL zibhalwe kahle kakhulu. Ikhonjiswe ukuthi iyasebenza ekulweni nohlu lwamabhaktheriya, isikhunta, namagciwane, okuyenza ibe enye indlela engasetshenziswa kuma-antibiotic avamile. Lokhu kubaluleke kakhulu uma kubhekwa inkinga ekhulayo yokungazweli ngama-antibiotic.

Ngaphezu kwezicelo zayo zokwelapha, i-berberine HCL iphinde yacwaningwa ngendima yayo engaba khona ekwehleni kwesisindo. Olunye ucwaningo lubonisa ukuthi lungasiza ekunciphiseni amafutha omzimba ngokuvimbela i-lipogenesis (inqubo yokuguqula ushukela ube ngamafutha) futhi ikhuthaze i-lipolysis (ukuwohloka kwamafutha). Kodwa-ke, ucwaningo olwengeziwe luyadingeka ukuze kuqinisekiswe lokhu okutholakele futhi kunqunywe umthamo ophelele wokuncipha kwesisindo.

Naphezu kwezinzuzo zayo ezingaba khona, i-berberine HCL ayikho ngaphandle kwemikhawulo yayo. Kuyaziwa ukuthi ine-bioavailability ephansi, okusho ukuthi ayimuncwa kalula ngumzimba. Ukwengeza, ukusetshenziswa kwesikhathi eside kungaholela kuma-microorganisms amelana ne-berberine, kunciphise ukusebenza kwawo ngokuhamba kwesikhathi. Ngakho-ke, kubalulekile ukuthi ucwaningo olwengeziwe lugxile ekuthuthukiseni i-bioavailability ye-berberine HCL kanye nokubhekana nezinkinga zayo zokumelana.

Sengiphetha, i-berberine HCL iyi-molecule ethakazelisayo enohlu lwezinhlelo zokusebenza zokwelapha ezingaba khona. Imisebenzi yayo ehlukahlukene yebhayoloji kanye nokusetshenziswa okungase kube khona ekwelapheni izifo ezahlukahlukene kuyenza ibe yindawo ethokozisayo yocwaningo. Kodwa-ke, ucwaningo olwengeziwe luyadingeka ukuze kuqondwe ngokugcwele izindlela zayo zokusebenza kanye nokwandisa ukusetshenziswa kwayo kuzilungiselelo zomtholampilo. Ngocwaningo oluqhubekayo nokuthuthukiswa, i-berberine HCL ngolunye usuku ingase ibe umdlali obalulekile emkhakheni wezokwelapha eziqondene nawe.