I-Berberine, noma i-berberine hydrochloride, iyinhlanganisela etholakala ezitshalweni eziningi. Ingasiza ekwelapheni izimo ezifana nesifo sikashukela, i-cholesterol ephezulu kanye nomfutho wegazi ophezulu. Kodwa-ke, imiphumela emibi ingafaka phakathi ukucasuka kwesisu kanye nesicanucanu.
I-Berberine ibilokhu iyingxenye yemithi yendabuko yaseShayina neye-Ayurvedic iminyaka eyizinkulungwane. Isebenza emzimbeni ngezindlela ezahlukene futhi iyakwazi ukudala izinguquko ngaphakathi kwamaseli omzimba.
Ucwaningo nge-berberine lusikisela ukuthi ingase yelaphe izifo ezahlukahlukene ze-metabolic, okuhlanganisa isifo sikashukela, ukukhuluphala ngokweqile, nesifo senhliziyo. Ingase futhi ithuthukise impilo yamathumbu.
Nakuba i-berberine ibonakala iphephile futhi inemiphumela emibi embalwa, kufanele uthintane nodokotela wakho ngaphambi kokuyithatha.
I-Berberine ingaba yi-ejenti ephumelelayo yokulwa namagciwane. Ucwaningo lwango-2022 luthole ukuthi i-berberine iyasiza ekuvimbeleni ukukhula kwe-Staphylococcus aureus.
Olunye ucwaningo luthole ukuthi i-berberine ingalimaza i-DNA namaprotheni amanye amabhaktheriya.
Ucwaningo lubonisa ukuthi i-berberine inezakhiwo zokulwa nokuvuvukala, okusho ukuthi ingasiza ekwelapheni isifo sikashukela nezinye izifo ezihambisana nokuvuvukala.
Ucwaningo lusikisela ukuthi i-berberine ingaba usizo ekwelapheni isifo sikashukela. Ucwaningo lukhombisile ukuthi ingaba nomthelela omuhle ku:
Ukuhlaziywa okufanayo kuthole ukuthi inhlanganisela ye-berberine nomuthi onciphisa ushukela egazini yayisebenza kangcono kunanoma yimuphi umuthi wodwa.
Ngokusho kocwaningo lwango-2014, i-berberine ithembisa njengendlela yokwelapha isifo sikashukela, ikakhulukazi kubantu abangakwazi ukuthatha imithi yokulwa nesifo sikashukela ekhona ngenxa yesifo senhliziyo, ukwehluleka kwesibindi, noma izinkinga zezinso.
Okunye ukubuyekezwa kwezincwadi kuthole ukuthi i-berberine kanye nezinguquko zendlela yokuphila kunciphisa amazinga kashukela egazini ngaphezu kwezinguquko zendlela yokuphila zodwa.
Kubonakala sengathi i-Berberine isebenzisa i-AMP-activated protein kinase, esiza ekulawuleni ukusetshenziswa koshukela egazini emzimbeni. Abacwaningi bakholelwa ukuthi lokhu kusebenza kungasiza ekwelapheni isifo sikashukela kanye nezinkinga zempilo ezihlobene nokukhuluphala kanye ne-cholesterol ephezulu.
Okunye ukuhlaziywa kwe-meta ka-2020 kubonise ukuthuthuka kwesisindo somzimba kanye nemingcele ye-metabolic ngaphandle kokwanda okukhulu komsebenzi we-enzyme yesibindi.
Kodwa-ke, ososayensi badinga ukwenza izifundo ezinkulu, ezingaboni kahle ukuze banqume ngokugcwele ukuphepha nokusebenza kahle kwe-berberine.
Khuluma nodokotela wakho ngaphambi kokuthatha i-berberine yesifo sikashukela. Ingase ingafaneleki kuwo wonke umuntu futhi ingase ihlangane neminye imithi.
Amazinga aphezulu e-cholesterol kanye ne-low-density lipoprotein (LDL) triglycerides angandisa ingozi yesifo senhliziyo kanye nesifo sohlangothi.
Ubufakazi obuthile busikisela ukuthi i-berberine ingasiza ekwehliseni i-cholesterol ye-LDL kanye ne-triglycerides. Ngokusho kokubuyekezwa okunye, izifundo zezilwane kanye nabantu zibonisa ukuthi i-berberine yehlisa i-cholesterol.
Lokhu kungasiza ukwehlisa i-LDL, i-cholesterol "embi", futhi kwandise i-HDL, i-cholesterol "enhle".
Ukubuyekezwa kwezincwadi kutholakale ukuthi i-berberine ehlanganiswe nezinguquko zendlela yokuphila iphumelela kakhulu ekwelapheni i-cholesterol ephezulu kunezinguquko zendlela yokuphila zodwa.
Abacwaningi bakholelwa ukuthi i-berberine ingase isebenze ngendlela efanayo nemithi yokwehlisa i-cholesterol ngaphandle kokubangela imiphumela emibi efanayo.
Ukubuyekezwa kwezincwadi kuthole ukuthi i-berberine yayisebenza kangcono uma ihlanganiswa nemithi yokwehlisa umfutho wegazi kunokuba isetshenziswe yodwa.
Ngaphezu kwalokho, imiphumela evela ezifundweni zamagundane iphakamisa ukuthi i-berberine ingase ilibazise ukuqala komfutho wegazi ophezulu futhi isize ekunciphiseni ubukhali bayo lapho kwenzeka umfutho wegazi ophezulu.
Ukubuyekezwa okunye kubikwe ukwehla okukhulu kwesisindo kubantu abathatha ama-milligram angu-750 (mg) e-barberry kabili ngosuku izinyanga ezi-3. I-Barberry iyisitshalo esiqukethe i-berberine eningi.
Ngaphezu kwalokho, ucwaningo olungaboni kahle luthole ukuthi abantu abane-metabolic syndrome abathatha ama-200 mg e-barberry kathathu ngosuku babene-body mass index ephansi.
Ithimba elenza olunye ucwaningo liphawule ukuthi i-berberine ingase isebenze izicubu zamafutha ansundu. Lezi zicubu zisiza umzimba ukuguqula ukudla kube ukushisa komzimba, futhi ukusebenza okwengeziwe kungasiza ekwelapheni ukukhuluphala kanye nesifo se-metabolic syndrome.
Ezinye izifundo zisikisela ukuthi i-berberine isebenza ngendlela efanayo nomuthi i-metformin, odokotela abavame ukuwunikeza ukwelapha isifo sikashukela sohlobo 2. Eqinisweni, i-berberine ingaba nekhono lokushintsha amagciwane amathumbu, okungasiza ekwelapheni ukukhuluphala nesifo sikashukela.
I-Polycystic ovary syndrome (PCOS) yenzeka lapho abesifazane benamazinga aphezulu ama-hormone athile wesilisa. Le syndrome iwukungalingani kwama-hormone kanye nokusetshenziswa kwe-metabolic okungaholela ekungazali kanye nezinye izinkinga zempilo.
I-Polycystic ovary syndrome ihlotshaniswa nezinkinga eziningi i-berberine engasiza ekuzixazululeni. Isibonelo, abantu abane-PCOS bangase babe nalokhu:
Odokotela ngezinye izikhathi banikeza i-metformin, umuthi wesifo sikashukela, ukwelapha i-PCOS. Njengoba i-berberine inemiphumela efanayo ne-metformin, ingaba yindlela enhle yokwelapha i-PCOS.
Ukubuyekezwa okuhlelekile kuthole ukuthi i-berberine iyathembisa ekwelapheni i-polycystic ovary syndrome enokumelana ne-insulin. Kodwa-ke, abalobi baphawula ukuthi ukuqinisekiswa kwale miphumela kudinga ucwaningo olwengeziwe.
I-Berberine ingabangela izinguquko kuma-molecule eseli, okungaba nenye inzuzo engaba khona: ukulwa nomdlavuza.
Olunye ucwaningo lubonisa ukuthi i-berberine iyasiza ekwelapheni umdlavuza ngokuvimbela ukuqhubeka kwawo kanye nomjikelezo wokuphila ojwayelekile. Ingadlala indima ekubulaleni amangqamuzana omdlavuza.
Ngokusekelwe kule mininingwane, abalobi bathi i-berberine iyisidakamizwa "esisebenza kahle kakhulu, esiphephile, futhi esingabizi kakhulu" sokulwa nomdlavuza.
Kodwa-ke, kubalulekile ukukhumbula ukuthi abacwaningi bafunde kuphela imiphumela ye-berberine kumaseli omdlavuza elabhorethri hhayi kubantu.
Ngokusho kwezinye izifundo ezanyatheliswa ngo-2020, uma i-berberine ingasiza ekwelapheni umdlavuza, ukuvuvukala, isifo sikashukela nezinye izifo, kungenzeka ukuthi kungenxa yemiphumela yayo emihle ku-gut microbiome. Ososayensi bathole ukuxhumana phakathi kwe-gut microbiome (amakholoni amabhaktheriya emathunjini) nalezi zimo.
I-Berberine inezakhiwo zokulwa namagciwane futhi isusa amagciwane ayingozi emathunjini, ngaleyo ndlela ikhuthaza ukukhula kwamagciwane anempilo.
Nakuba izifundo kubantu nasemagundwini zisikisela ukuthi lokhu kungaba yiqiniso, ososayensi baxwayisa ngokuthi kudingeka ucwaningo olwengeziwe ukuqinisekisa ukuthi i-berberine ibathinta kanjani abantu nokuthi iphephile yini ukuyisebenzisa.
I-American Association of Naturopathic Physicians (AANP) ithi izithako ze-berberine ziyatholakala ngesimo sezithasiselo noma se-capsule.
Banezela ngokuthi izifundo eziningi zincoma ukuthatha u-900-1500 mg ngosuku, kodwa abantu abaningi bathatha u-500 mg kathathu ngosuku. Kodwa-ke, i-AANP inxusa abantu ukuthi babonane nodokotela ngaphambi kokuthatha i-berberine ukuze bahlole ukuthi iphephile yini ukuyisebenzisa nokuthi ingathathwa ngamuphi umthamo.
Uma udokotela evuma ukuthi i-berberine iphephile ukuyisebenzisa, abantu kufanele bahlole nelebula lomkhiqizo ukuze bathole isitifiketi esivela kubantu besithathu, njenge-National Science Foundation (NSF) noma i-NSF International, kusho i-AANP.
Ababhali bocwaningo lwango-2018 bathole ukuthi okuqukethwe kwama-capsule e-berberine ahlukene kwahlukahluka kakhulu, okungaholela ekudidekeni mayelana nokuphepha kanye nomthamo. Abatholanga ukuthi izindleko eziphakeme zibonisa ikhwalithi ephezulu yomkhiqizo.
I-US Food and Drug Administration (FDA) ayilawuli izithasiselo zokudla. Akukho siqinisekiso sokuthi izithasiselo ziphephile noma ziyasebenza, futhi akunakwenzeka njalo ukuqinisekisa ikhwalithi yomkhiqizo.
Ososayensi bathi i-berberine ne-metformin zinezici eziningi futhi zombili zingaba usizo ekwelapheni isifo sikashukela sohlobo 2.
Kodwa-ke, uma udokotela enikeza umuntu i-metformin, akufanele acabangele i-berberine njengenye indlela ngaphandle kokuxoxa ngayo nodokotela wakhe kuqala.
Odokotela bazonikeza umuntu umthamo ofanele we-metformin ngokusekelwe ezifundweni zezokwelapha. Akunakwenzeka ukwazi ukuthi izithasiselo zihambisana kahle kangakanani naleli nani.
I-Berberine ingasebenzisana ne-metformin futhi ithinte ushukela wegazi lakho, okwenza kube nzima ukuyilawula. Kokunye ukuhlola, ukuthatha i-berberine ne-metformin ndawonye kunciphisa imiphumela ye-metformin ngo-25%.
I-Berberine ingase ibe yindlela efanelekile yokulawula ushukela egazini ngelinye ilanga, kodwa kudingeka ucwaningo olwengeziwe.
I-National Center for Complementary and Integrative Health (NCCIH) ithi i-goldenrod, equkethe i-berberine, cishe ngeke ibangele imiphumela emibi kakhulu esikhathini esifushane uma abantu abadala beyiphuza ngomlomo. Kodwa-ke, akukho ulwazi olwanele lokubonisa ukuthi iphephile ukusetshenziswa isikhathi eside.
Ezifundweni zezilwane, ososayensi baphawule imiphumela elandelayo kuye ngohlobo lwesilwane, inani kanye nobude bokuphathwa kwaso:
Kubalulekile ukukhuluma nodokotela wakho ngaphambi kokuthatha i-berberine noma ezinye izithako ngoba zingase zingaphephile futhi zingase zingafaneleki kuwo wonke umuntu. Noma ubani onenkinga yokungezwani komzimba nanoma yimuphi umkhiqizo wezitshalo kufanele ayeke ukuwusebenzisa ngokushesha.