Isengezo esibizwa ngokuthi i-5-hydroxytryptophan (5-HTP) noma i-osetriptan sibhekwa njengenye yezindlela zokwelapha ikhanda kanye ne-migraines. Umzimba uguqula lesi sidakamizwa sibe yi-serotonin (5-HT), eyaziwa nangokuthi i-serotonin, i-neurotransmitter elawula isimo sengqondo kanye nobuhlungu.
Amazinga aphansi e-serotonin avame ukubonakala kubantu abanokucindezeleka, kodwa abantu abaphethwe yi-migraine kanye nabantu abaphethwe yikhanda elingapheli bangase babe namazinga aphansi e-serotonin ngesikhathi naphakathi kokuhlaselwa. Akucaci ukuthi kungani i-migraines ne-serotonin kuhlobene. Inkolelo-mbono ethandwa kakhulu ukuthi ukuntuleka kwe-serotonin kwenza abantu bazwele kakhulu ubuhlungu.
Ngenxa yalokhu kuxhumana, izindlela eziningana zokwandisa umsebenzi we-serotonin ebuchosheni zivame ukusetshenziswa ukuvimbela i-migraines nokwelapha ukuhlaselwa okubukhali.
I-5-HTP iyi-amino acid ekhiqizwa umzimba nge-amino acid ebalulekile i-L-tryptophan futhi kumele itholakale ekudleni. I-L-tryptophan itholakala ekudleni okufana nembewu, ubhontshisi, i-turkey kanye noshizi. Ama-enzyme ngokwemvelo aguqula i-L-tryptophan ibe yi-5-HTP, bese iguqula i-5-HTP ibe yi-5-HT.
Izithasiselo ze-5-HTP zenziwe ngesitshalo semithi saseNtshonalanga Afrika iGriffonia simplicifolia. Lesi sithasiselo sisetshenziswe ekwelapheni ukucindezeleka, i-fibromyalgia, i-chronic fatigue syndrome, kanye nokwehlisa isisindo, kodwa abukho ubufakazi obuqinisekile bezinzuzo zaso.
Uma ucabangela i-5-HTP noma yisiphi isithasiselo semvelo, kubalulekile ukuqonda ukuthi le mikhiqizo ingamakhemikhali. Uma uyithatha ngoba inamandla ngokwanele ukuba nomthelela omuhle empilweni yakho, khumbula ukuthi ingaba namandla ngokwanele ukuba nemiphumela emibi.
Akucaci ukuthi izithasiselo ze-5-HTP ziwusizo yini ekwelapheni ikhanda elibuhlungu noma ezinye izinhlobo zekhanda elibuhlungu. Sekukonke, ucwaningo lulinganiselwe; ezinye izifundo zibonisa ukuthi ziyasiza, kanti ezinye azibonisi mphumela.
Izifundo ze-migraine zisebenzise imithamo ye-5-HTP esukela ku-25 kuya ku-200 mg ngosuku kubantu abadala. Okwamanje akukho mithamo ecacile noma enconyiwe yalesi sengezo, kodwa kubalulekile ukuqaphela ukuthi imithamo ephezulu ihlotshaniswa nemiphumela emibi kanye nokusebenzisana kwezidakamizwa.
I-5-HTP ingasebenzisana neminye imithi, okuhlanganisa ne-carbidopa, esetshenziselwa ukwelapha isifo sikaParkinson. Ingase futhi ihlanganyele nama-triptan, ama-SSRI, kanye nama-monoamine oxidase inhibitors (ama-MAOI, olunye uhlobo lwemithi yokucindezeleka).
Izithako ze-Tryptophan kanye ne-5-HTP zingase zingcoliswe yisithako semvelo i-4,5-tryptophanione, i-neurotoxin eyaziwa nangokuthi i-Peak X. Imiphumela yokuvuvukala kwe-Peak X ingabangela ubuhlungu bemisipha, ukuqaqamba, kanye nomkhuhlane. Imiphumela yesikhathi eside ingafaka phakathi ukulimala kwemisipha kanye nemizwa.
Ngenxa yokuthi leli khemikhali liwumphumela wokusabela kwamakhemikhali hhayi ukungcola noma ukungcola, lingatholakala ezithasiselweni noma ngabe zilungiselelwe ngaphansi kwezimo zokuhlanzeka.
Kubalulekile ukuxoxa ngokuthatha noma yiziphi izithasiselo nodokotela wakho noma usokhemisi ukuze uqiniseke ukuthi ziphephile kuwe futhi ngeke zihlangane neminye imithi yakho.
Khumbula ukuthi izithako zokudla kanye nezithako zamakhambi azikaze zihlolwe futhi zihlolwe ngendlela efanayo nemithi ethengiswa ngaphandle kwemithi kadokotela kanye nemithi kadokotela, okusho ukuthi ucwaningo olusekela ukusebenza kahle kwayo kanye nokuphepha kwayo lulinganiselwe noma aluphelele.
Izithasiselo kanye nemithi yemvelo ingaba yinhle, ikakhulukazi uma ingenayo imiphumela emibi. Eqinisweni, imithi yemvelo iye yabonakala isebenza kahle ezifweni eziningi. Kunobufakazi bokuthi izithasiselo ze-magnesium zinganciphisa ukuvama kanye nobukhali bokuhlaselwa yi-migraine. Kodwa-ke, akucaci ukuthi i-5-HTP iwusizo yini kuma-migraine.
UHorvath GA, uSelby K, uPoskitt K, nabanye. Izelamani ezinezinga eliphansi le-serotonin emzimbeni ziba ne-hemiplegic migraine, ukuxhuzula, ukukhubazeka okuqhubekayo kwe-spastic, ukuphazamiseka kwemizwelo, kanye ne-coma. Ikhanda elibuhlungu. 2011;31(15):1580-1586. Inombolo: 10.1177/0333102411420584.
U-Aggarwal M, uPuri V, uPuri S. I-Serotonin kanye ne-CGRP ku-migraine. I-Ann Neuroscience. 2012;19(2):88–94. doi:10.5214/ans.0972.7531.12190210
UChauvel V, uMoulton S, uChenin J. Imiphumela encike ku-estrogen ye-5-hydroxytryptophan ekusakazeni ukucindezeleka kwe-cortical kumagundane: ukulingisa ukusebenzisana kwe-serotonin kanye ne-ovarian hormone ku-migraine aura. Ikhanda elibuhlungu. 2018;38(3):427-436. Inombolo: 10.1177/0333102417690891
UVictor S., uRyan SV Imithi yokuvimbela i-migraine ezinganeni. I-Cochrane Database Syst Rev 2003;(4):CD002761. Inombolo: 10.1002/14651858.CD002761
Das YT, Bagchi M., Bagchi D., Preus HG Ukuphepha kwe-5-hydroxy-L-tryptophan. Izincwadi eziphathelene nobuthi. 2004;150(1):111-22. doi:10.1016/j.toxlet.2003.12.070
UTeri Robert UTeri Robert ungumbhali, umfundisi weziguli, kanye nommeli weziguli ogxile ezinkingeni zekhanda kanye nekhanda elibuhlungu.