Umzimba wakho uwusebenzisa ukuze ukhiqize i-serotonin, isithunywa samakhemikhali esithumela izimpawu phakathi kwamangqamuzana ezinzwa.
I-serotonin ephansi iye yaxhunyaniswa nokucindezeleka, ukukhathazeka, ukuphazamiseka kokulala, ukuzuza isisindo, nezinye izinkinga zempilo (1, 2).
Ukuncipha kwesisindo kwandisa ukukhiqizwa kwamahomoni abangela indlala. Lo muzwa oqhubekayo wokulamba ungenza ukuncipha kwesisindo kungapheli ngokuhamba kwesikhathi (3, 4, 5).
I-5-HTP ingase imelane nalawa mahomoni abangela indlala acindezela ukudla futhi akusize ulahlekelwe isisindo (6).
Ocwaningweni olulodwa, iziguli ezinesifo sikashukela ezingama-20 zabelwa ngokungahleliwe ukuthola i-5-HTP noma i-placebo amasonto amabili. Imiphumela yabonisa ukuthi labo abathola i-5-HTP badle cishe ama-calories angu-435 ambalwa ngosuku uma kuqhathaniswa neqembu le-placebo (7).
Ngaphezu kwalokho, i-5-HTP icindezela ngokuyinhloko ukudla kwe-carbohydrate, okuhlotshaniswa nokulawulwa okungcono kwe-glycemic (7).
Ezinye izifundo eziningi nazo zibonise ukuthi i-5-HTP inyusa ukusutha futhi ikhuthaza ukuncipha kwesisindo kubantu abakhuluphele noma abakhuluphele (8, 9, 10, 11).
Ngaphezu kwalokho, izifundo zezilwane zibonise ukuthi i-5-HTP inganciphisa ukudla ngokweqile ngenxa yokucindezeleka noma ukucindezeleka (12, 13).
I-5-HTP ingase isebenze ekwandiseni ukusutha, okungakusiza ukuthi udle kancane futhi ulahlekelwe isisindo.
Yize imbangela yangempela yokudangala ingaziwa kakhulu, abanye abacwaningi bakholelwa ukuthi ukungalingani kwe-serotonin kungathinta imizwa yakho, okuholela ekucindezelekeni (14, 15).
Eqinisweni, izifundo ezimbalwa ezincane zibonise ukuthi i-5-HTP inganciphisa izimpawu zokucindezeleka. Kodwa-ke, ababili babo abazange basebenzise i-placebo ukuze baqhathanise, okukhawulela ukufaneleka kwemiphumela yabo (16, 17, 18, 19).
Kodwa-ke, ucwaningo oluningi luye lwabonisa ukuthi i-5-HTP inomphumela onamandla onamandla wokudambisa ukucindezeleka uma isetshenziswa ngokuhlanganiswa nezinye izinto noma ama-antidepressants kunalapho isetshenziswa yodwa (17, 21, 22, 23).
Ngaphezu kwalokho, ukubuyekezwa okuningi kuphethe ngokuthi ucwaningo oluphezulu lwezinga eliphezulu luyadingeka ngaphambi kokuthi i-5-HTP inganconywa ekwelapheni ukucindezeleka (24, 25).
Izithako ze-5-HTP zandisa amazinga e-serotonin emzimbeni, ezingadambisa izimpawu zokucindezeleka, ikakhulukazi uma zihlangene nezinye izidakamizwa noma imithi. Nokho, ucwaningo olwengeziwe luyadingeka.
Ukwengezwa kwe-5-HTP kungase kuthuthukise izimpawu ze-fibromyalgia, isifo esibonakala ngobuhlungu bemisipha namathambo kanye nobuthakathaka obujwayelekile.
Okwamanje asikho isizathu esaziwayo se-fibromyalgia, kodwa amazinga aphansi e-serotonin axhunywe kulesi simo ( 26Trusted Source ).
Lokhu kuholela abacwaningi ukuthi bakholelwe ukuthi ukukhulisa amazinga e-serotonin ngezithako ze-5-HTP kungase kuzuze abantu abane-fibromyalgia (27).
Eqinisweni, ubufakazi bokuqala bubonisa ukuthi i-5-HTP ingase ithuthukise izimpawu ze-fibromyalgia, kuhlanganise nobuhlungu bemisipha, izinkinga zokulala, ukukhathazeka, nokukhathala (28, 29, 30).
Kodwa-ke, akwenziwanga ucwaningo olwanele ukuze kufinyelelwe iziphetho eziqinile mayelana nokusebenza kwe-5-HTP ekuthuthukiseni izimpawu ze-fibromyalgia.
I-5-HTP inyusa amazinga e-serotonin emzimbeni, engakhulula ezinye zezimpawu ze-fibromyalgia. Nokho, ucwaningo olwengeziwe luyadingeka.
I-5-HTP kuthiwa isiza ukwelapha i-migraines, uhlobo lwekhanda elivame ukuhambisana nesicanucanu noma ukuphazamiseka okubukwayo.
Nakuba imbangela yabo yangempela iphikiswana ngayo, abanye abacwaningi bakholelwa ukuthi ibangelwa amazinga aphansi e-serotonin (31, 32).
Ucwaningo lwabantu abangu-124 luqhathanise ikhono le-5-HTP ne-methylergometrine, imithi evamile ye-migraine, ukuvimbela ubuhlungu bekhanda le-migraine (33).
Ucwaningo luthole ukuthi ukuthatha i-5-HTP nsuku zonke izinyanga eziyisithupha kuvimbela noma kunciphisa kakhulu inani lokuhlaselwa kwe-migraine ku-71% yabahlanganyeli (33).
Kwesinye isifundo sabafundi be-48, i-5-HTP yehlise imvamisa yekhanda ngama-70% uma iqhathaniswa ne-11% eqenjini le-placebo (34).
Ngokufanayo, ezinye izifundo eziningi zibonise ukuthi i-5-HTP ingaba ukwelashwa okuphumelelayo kwe-migraines (30, 35, 36).
I-Melatonin idlala indima ebalulekile ekulawuleni ukulala. Amazinga ayo aqala ukukhuphuka ebusuku ukuze akhuthaze ukulala futhi awe ekuseni ukuze akusize uvuke.
Ngakho-ke, ukwesekwa kwe-5-HTP kungase kukhuthaze ukulala ngokwandisa ukukhiqizwa kwe-melatonin emzimbeni.
Ucwaningo lwabantu luthole ukuthi inhlanganisela ye-5-HTP ne-gamma-aminobutyric acid (GABA) inciphise kakhulu isikhathi esisithathayo ukuze ulale, ubude besikhathi sokulala, kanye nekhwalithi yokulala ethuthukisiwe (37).
I-GABA iyisithunywa samakhemikhali esikhuthaza ukuphumula. Ukuyihlanganisa ne-5-HTP kungase kube nomphumela we-synergistic (37).
Eqinisweni, izifundo ezimbalwa zezilwane nezinambuzane zibonise ukuthi i-5-HTP ithuthukisa ikhwalithi yokulala futhi iba ngcono nakakhulu uma ihlanganiswe ne-GABA (38, 39).
Nakuba le miphumela ithembisa, ukuntuleka kwezifundo zabantu kwenza kube nzima ukuncoma i-5-HTP yokuthuthukisa ikhwalithi yokulala, ikakhulukazi uma isetshenziswa iyodwa.
Abanye abantu bangase babe nesicanucanu, isifo sohudo, ukuhlanza, nobuhlungu besisu ngenkathi bethatha izithasiselo ze-5-HTP. Le miphumela emibi incike kumthamo, okusho ukuthi iba yimbi kakhulu njengoba umthamo ukhula (33).
Ukuze unciphise le miphumela engemihle, qala ngomthamo wama-50-100 mg kabili ngosuku bese ukhuphukela kumthamo ofanele emasontweni amabili (40).
Eminye imithi yandisa ukukhiqizwa kwe-serotonin. Ukuhlanganisa le mithi ne-5-HTP kungabangela amazinga ayingozi e-serotonin emzimbeni. Lokhu kubizwa nge-serotonin syndrome, isimo esingase sibe yingozi empilweni (41).
Imithi engakhuphula amazinga e-serotonin emzimbeni ihlanganisa ama-antidepressants athile, imithi yokukhwehlela, noma izidambisi zezinhlungu ezinikezwa ngudokotela.
Ngenxa yokuthi i-5-HTP ingase futhi ikhuthaze ukulala, ukuyiphuza namaphilisi okulalisa umzimba afana ne-Klonopin, i-Ativan, noma i-Ambien kungase kubangele ubuthongo obuningi.
Ngenxa yokusebenzelana okungalungile okungenzeka neminye imithi, hlola nodokotela wakho noma usokhemisi ngaphambi kokuthatha izithasiselo ze-5-HTP.
Lapho uthenga izithasiselo, bheka izigxivizo ze-NSF noma ze-USP ezibonisa ikhwalithi ephezulu. Lezi izinkampani zezinkampani zangaphandle eziqinisekisa ukuthi izithasiselo ziqukethe lokho okushiwo kulebula futhi azinakho ukungcola.
Abanye abantu bangase babe nemiphumela engemihle lapho bethatha izithasiselo ze-5-HTP. Hlola nodokotela wakho ngaphambi kokuthatha i-5-HTP ukuze uqiniseke ukuthi iphephile kuwe.
Lezi zithako zihlukile kunezithako ze-L-tryptophan, ezingase futhi zikhulise amazinga e-serotonin (42).
I-L-tryptophan iyi-amino acid ebalulekile etholakala ekudleni okunamaprotheni amaningi njengobisi, izinkukhu, inyama, uphizi, nesoya.
Ngakolunye uhlangothi, i-5-HTP ayitholakali ekudleni futhi ingangezwa kuphela ekudleni kwakho ngokusebenzisa izithasiselo zokudla (43).
Umzimba wakho uguqula i-5-HTP ibe i-serotonin, into elawula ukudla, ukubona ubuhlungu, nokulala.
Amazinga aphezulu e-serotonin angaba nezinzuzo eziningi, njengokuncipha kwesisindo, ukukhululeka ezimpawini zokucindezeleka kanye ne-fibromyalgia, imvamisa encishisiwe yokuhlaselwa yi-migraine, nokulala okungcono.
Imiphumela emibi emincane iye yahlotshaniswa ne-5-HTP, kodwa lokhu kungancishiswa ngokuqala ngemithamo emincane futhi kancane kancane ukwandisa umthamo.
Njengoba kunikezwe ukuthi i-5-HTP ingase ihlanganyele kabi nemithi ethile, thintana nodokotela wakho ukuze uqiniseke ukuthi iphephile kuwe.
Ochwepheshe bethu bahlala beqapha indawo yezempilo nokuphila kahle futhi babuyekeza ama-athikili ethu njengoba ulwazi olusha lutholakala.
I-5-HTP ivame ukusetshenziswa njengesengezo sokwandisa amazinga e-serotonin. Ubuchopho busebenzisa i-serotonin ukulawula imizwa, isifiso sokudla, neminye imisebenzi ebalulekile. kodwa…
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