Umzimba wakho uyisebenzisela ukukhiqiza i-serotonin, isithunywa samakhemikhali esithumela izimpawu phakathi kwamangqamuzana ezinzwa.
I-serotonin ephansi ihlotshaniswa nokucindezeleka, ukukhathazeka, ukuphazamiseka kokulala, ukukhuluphala, kanye nezinye izinkinga zempilo (1, 2).
Ukwehlisa isisindo kwandisa ukukhiqizwa kwama-hormone abangela indlala. Lo muzwa oqhubekayo wendlala ungenza ukwehla kwesisindo kungaqhubeki ngokuhamba kwesikhathi (3, 4, 5).
I-5-HTP ingase imelane nala ma-hormone abangela indlala acindezela isifiso sokudla futhi akusize wehlise isisindo (6).
Kokunye ukuhlola, iziguli ezingu-20 ezinesifo sikashukela zabelwa ngokungahleliwe ukuthi zithole i-5-HTP noma i-placebo amasonto amabili. Imiphumela ibonise ukuthi labo abathole i-5-HTP badle cishe amakhalori angu-435 angaphansi ngosuku uma kuqhathaniswa neqembu le-placebo (7).
Ngaphezu kwalokho, i-5-HTP ngokuyinhloko icindezela ukudla ama-carbohydrate, okuhambisana nokulawula okungcono kwe-glycemic (7).
Ezinye izifundo eziningi zikhombisile nokuthi i-5-HTP ikhulisa ukusutha futhi ikhuthaza ukwehla kwesisindo kubantu abakhuluphele ngokweqile noma abakhuluphele ngokweqile (8, 9, 10, 11).
Ngaphezu kwalokho, izifundo zezilwane zikhombisile ukuthi i-5-HTP inganciphisa ukudla ngokweqile ngenxa yokucindezeleka noma ukucindezeleka (12, 13).
I-5-HTP ingaba wusizo ekwandiseni ukusutha, okungakusiza ukuthi udle kancane futhi wehlise isisindo.
Nakuba imbangela eqondile yokucindezeleka ingaziwa kakhulu, abanye abacwaningi bakholelwa ukuthi ukungalingani kwe-serotonin kungathinta isimo sakho sengqondo, okuholela ekucindezelekeni (14, 15).
Eqinisweni, izifundo eziningana ezincane zikhombisile ukuthi i-5-HTP inganciphisa izimpawu zokucindezeleka. Kodwa-ke, ezimbili zazo azizange zisebenzise i-placebo ukuqhathanisa, okwanciphisa ukusebenza kwemiphumela yazo (16, 17, 18, 19).
Kodwa-ke, izifundo eziningi zikhombisile ukuthi i-5-HTP inomphumela onamandla wokucindezeleka uma isetshenziswa kanye nezinye izinto noma imithi yokucindezeleka kunalapho isetshenziswa yodwa (17, 21, 22, 23).
Ngaphezu kwalokho, ukubuyekezwa okuningi kuphethe ngokuthi kudingeka ucwaningo olusezingeni eliphezulu ngaphambi kokuba kunconywe i-5-HTP ekwelapheni ukucindezeleka (24, 25).
Izithako ze-5-HTP zandisa amazinga e-serotonin emzimbeni, okunganciphisa izimpawu zokucindezeleka, ikakhulukazi uma kuhlanganiswa neminye imithi yokucindezeleka noma imithi. Kodwa-ke, kudingeka ucwaningo olwengeziwe.
Ukwengezwa kwe-5-HTP kungathuthukisa izimpawu ze-fibromyalgia, isifo esibonakala ngobuhlungu bemisipha namathambo kanye nobuthakathaka obujwayelekile.
Okwamanje asikho isizathu esaziwayo se-fibromyalgia, kodwa amazinga aphansi e-serotonin ahlotshaniswa nalesi simo (26Trusted Source).
Lokhu kwenza abacwaningi bakholelwe ukuthi ukukhulisa amazinga e-serotonin ngezithasiselo ze-5-HTP kungabazuzisa abantu abane-fibromyalgia (27).
Eqinisweni, ubufakazi bokuqala busikisela ukuthi i-5-HTP ingathuthukisa izimpawu ze-fibromyalgia, okuhlanganisa ubuhlungu bemisipha, izinkinga zokulala, ukukhathazeka, kanye nokukhathala (28, 29, 30).
Kodwa-ke, akwenziwanga ucwaningo olwanele ukuze kufinyelelwe eziphethweni eziqinile mayelana nokusebenza kahle kwe-5-HTP ekuthuthukiseni izimpawu ze-fibromyalgia.
I-5-HTP inyusa amazinga e-serotonin emzimbeni, okungaqeda ezinye zezimpawu ze-fibromyalgia. Kodwa-ke, kudingeka ucwaningo olwengeziwe.
Kuthiwa i-5-HTP iyasiza ekwelapheni i-migraines, uhlobo lwekhanda elivame ukuhambisana nesicanucanu noma ukuphazamiseka kokubona.
Nakuba imbangela yazo eqondile iphikiswana ngayo, abanye abacwaningi bakholelwa ukuthi zibangelwa amazinga aphansi e-serotonin (31, 32).
Ucwaningo lwabantu abangu-124 luqhathanise ikhono le-5-HTP kanye ne-methylergometrine, umuthi ovamile we-migraine, lokuvimbela ikhanda le-migraine (33).
Ucwaningo luthole ukuthi ukuthatha i-5-HTP nsuku zonke izinyanga eziyisithupha kuvimbela noma kunciphisa kakhulu inani lokuhlaselwa yikhanda elibuhlungu ku-71% wabahlanganyeli (33).
Kolunye ucwaningo lwabafundi abangu-48, i-5-HTP yehlise imvamisa yekhanda ngo-70% uma kuqhathaniswa no-11% eqenjini le-placebo (34).
Ngokufanayo, ezinye izifundo eziningi zikhombisile ukuthi i-5-HTP ingaba ukwelashwa okuphumelelayo kwe-migraines (30, 35, 36).
I-Melatonin idlala indima ebalulekile ekulawuleni ubuthongo. Amazinga ayo aqala ukukhuphuka ebusuku ukuze kukhuthazwe ubuthongo futhi ehle ekuseni ukuze ikusize uvuke.
Ngakho-ke, ukwengezwa kwe-5-HTP kungakhuthaza ubuthongo ngokwandisa ukukhiqizwa kwe-melatonin emzimbeni.
Ucwaningo lwabantu luthole ukuthi inhlanganisela ye-5-HTP kanye ne-gamma-aminobutyric acid (GABA) inciphise kakhulu isikhathi esithathwayo ukuze ulale, yandise isikhathi sokulala, futhi yathuthukisa ikhwalithi yokulala (37).
I-GABA iyisithunywa samakhemikhali esikhuthaza ukuphumula. Ukuyihlanganisa ne-5-HTP kungaba nomphumela wokubambisana (37).
Eqinisweni, izifundo eziningana zezilwane nezinambuzane zibonise ukuthi i-5-HTP ithuthukisa ikhwalithi yokulala futhi ingcono nakakhulu uma ihlanganiswa ne-GABA (38, 39).
Nakuba le miphumela ithembisa, ukuntuleka kwezifundo zabantu kwenza kube nzima ukuncoma i-5-HTP yokuthuthukisa ikhwalithi yokulala, ikakhulukazi uma isetshenziswa yodwa.
Abanye abantu bangase babe nesicanucanu, uhudo, ukuhlanza, kanye nobuhlungu besisu ngenkathi bethatha izithasiselo ze-5-HTP. Le miphumela emibi incike kumthamo, okusho ukuthi iba mibi kakhulu njengoba umthamo ukhuphuka (33).
Ukuze unciphise le miphumela emibi, qala ngomthamo ongu-50–100 mg kabili ngosuku bese ukhuphula umthamo ube umthamo ofanele emavikini amabili (40).
Eminye imithi ikhulisa ukukhiqizwa kwe-serotonin. Ukuhlanganisa le mithi ne-5-HTP kungabangela amazinga ayingozi e-serotonin emzimbeni. Lokhu kubizwa ngokuthi i-serotonin syndrome, isimo esingaba yingozi empilweni (41).
Imithi engandisa amazinga e-serotonin emzimbeni ihlanganisa imithi ethile yokucindezeleka, imithi yokukhwehlela, noma imithi yokunciphisa izinhlungu enikezwa ngudokotela.
Ngenxa yokuthi i-5-HTP ingakhuthaza nokulala, ukuyithatha ngemithi yokudambisa enikezwa ngudokotela njenge-Klonopin, i-Ativan, noma i-Ambien kungabangela ukozela ngokweqile.
Ngenxa yokuxhumana okungekuhle okungenzeka neminye imithi, hlola nodokotela wakho noma usokhemisi ngaphambi kokuthatha izithasiselo ze-5-HTP.
Uma uthenga izithasiselo, funa izisimbiso ze-NSF noma ze-USP ezibonisa ikhwalithi ephezulu. Lezi yizinkampani zangaphandle eziqinisekisa ukuthi izithasiselo ziqukethe lokho okushiwo kulebula futhi azinazo izinto ezingcolile.
Abanye abantu bangase babe nemiphumela emibi lapho bethatha izithasiselo ze-5-HTP. Buza udokotela wakho ngaphambi kokuthatha i-5-HTP ukuqinisekisa ukuthi iphephile kuwe.
Lezi zithako zihlukile kunezithako ze-L-tryptophan, ezingakhuphula namazinga e-serotonin (42).
I-L-tryptophan iyi-amino acid ebalulekile etholakala ekudleni okucebile ngamaprotheni njengobisi, inkukhu, inyama, ubhontshisi kanye nesoya.
Ngakolunye uhlangothi, i-5-HTP ayitholakali ekudleni futhi ingafakwa ekudleni kwakho kuphela ngezithako zokudla (43).
Umzimba wakho uguqula i-5-HTP ibe yi-serotonin, into elawula isifiso sokudla, ukuqonda ubuhlungu, kanye nokulala.
Amazinga aphezulu e-serotonin angaba nezinzuzo eziningi, njengokunciphisa isisindo, ukukhululeka ezimpawini zokucindezeleka kanye ne-fibromyalgia, ukwehla kwemvamisa yokuhlaselwa yi-migraine, kanye nokulala kangcono.
Imiphumela emibi emincane ihlotshaniswa ne-5-HTP, kodwa lokhu kungancishiswa ngokuqala ngemithamo emincane bese ukhulisa kancane kancane umthamo.
Njengoba i-5-HTP ingase ingasebenzi kahle nemithi ethile, xhumana nodokotela wakho ukuqinisekisa ukuthi iphephile kuwe.
Ochwepheshe bethu bahlala beqapha indawo yezempilo kanye nenhlalakahle futhi babuyekeza izihloko zethu njengoba ulwazi olusha lutholakala.
I-5-HTP ivame ukusetshenziswa njengesengezo sokwandisa amazinga e-serotonin. Ubuchopho busebenzisa i-serotonin ukulawula isimo sengqondo, isifiso sokudla, kanye neminye imisebenzi ebalulekile. kodwa…
I-Xanax ilapha kanjani ukucindezeleka? I-Xanax ivame ukusetshenziswa ekwelapheni ukukhathazeka kanye nezinkinga zokwethuka.