Sisebenzisa amakhukhi ukuthuthukisa ulwazi lwakho.Ngokuqhubeka nokuphequlula leli sayithi, uyavumelana nokusebenzisa kwethu amakhukhi.Ulwazi olwengeziwe.
Ngokuchofoza okuthi “Vumela Konke”, uvumelana nokugcinwa kwamakhukhi kudivayisi yakho ukuze kuthuthukiswe ukuzulazula kwesayithi, ukuhlaziya ukusetshenziswa kwesayithi, futhi usekele ukunikezwa kwethu kokuqukethwe kwesayensi yokufinyelela mahhala, okuvulekile.Ulwazi olwengeziwe.
Ocwaningweni lwakamuva olushicilelwe kumagazini i-Pharmaceutics, abacwaningi banqume ukusebenza kahle kwe-antimicrobial yefomula ye-herbal ebizwa ngokuthi i-FRO ngokumelene ne-acne pathogenesis.
Ukuhlolwa kwe-antimicrobial kanye nokuhlaziywa kwe-in vitro kubonise ukuthi i-FRO inemiphumela ebalulekile yokulwa namagciwane kanye ne-anti-inflammatory ngokumelene ne-Dermatobacillus Acnes (CA), ibhaktheriya ebangela izinduna.Le miphumela ibonisa ukusetshenziswa kwayo okuphephile nokungokwemvelo ekwelapheni kwezimonyo zezinduna, isekela ukusetshenziswa kwezindlela ezingezona ezinobuthi nezingabizi kakhulu emithini yamanje yezinduna.
Ucwaningo: Ukusebenza kwe-FRO ku-pathogenesis ye-acne vulgaris.Ikhredithi yesithombe: Steve Jungs/Shutterstock.com
I-acne vulgaris, evame ukubizwa ngokuthi ama-pimples, yisimo sesikhumba esivamile esibangelwa izintambo zezinwele ezivalekile ezine-sebum namaseli esikhumba afile.Izinduna zithinta amaphesenti angaphezu kwangu-80 entsha futhi, nakuba zingabulali, zingabangela ukucindezeleka kwengqondo futhi, ezimweni ezimbi kakhulu, ukubukeka kwesikhumba unomphela kanye nezibazi.
Izinduna zibangelwa ukusebenzisana kwezakhi zofuzo kanye nemvelo, ngokuvamile okubangelwa izinguquko zamahomoni ezihambisana nokuthomba ngesikhathi sokuthomba.Lokhu kungalingani kwe-hormonal kukhulisa ukukhiqizwa kwe-sebum futhi kwandise ukukhula kwe-insulin factor 1 (IGF-1) kanye nomsebenzi we-dihydrotestosterone (DHT).
Ukwanda kwe-sebum secretion kubhekwa njengesigaba sokuqala ekukhuleni kwezinduna, ngoba izinwele zezinwele ezigcwele i-sebum ziqukethe inani elikhulu lama-microorganisms afana ne-SA.I-SA iyinto engokwemvelo ye-commensal yesikhumba;kodwa-ke, ukwanda okwandisiwe kwe-phylotype IA1 yayo kubangela ukuvuvukala kanye ne-pigmentation yezinwele zezinwele ezinama-papules abonakala ngaphandle.
Kunezinhlobo zokwelapha ezihlukene zezimonyo zezinduna, njengama-retinoids nama-topical microbial agents, asetshenziswa ngokuhlanganiswa namakhasi amakhemikhali, ukwelapha nge-laser/light, nama-hormone.Nokho, lezi zindlela zokwelapha zibiza kakhulu futhi zihlotshaniswa nemiphumela engemihle emibi.
Ucwaningo lwangaphambilini luhlole okukhishwe kwamakhambi njengendlela ehlukile yemvelo engabizi yalokhu kwelashwa.Njengenye indlela, okukhishwe kwe-Rhus vulgaris (RV) kuhlolisisiwe.Kodwa-ke, ukusetshenziswa kwayo kunqunyelwe i-urushiol, ingxenye eyinhloko ye-allergenic yalesi sihlahla.
I-FRO iyifomula ye-herbal equkethe okukhishwe okubilile kwe-RV (FRV) ne-Japanese mangosteen (OJ) ngesilinganiso esingu-1:1.Ukusebenza kwefomula kuhlolwe kusetshenziswa ama-in vitro assays kanye nezakhiwo ze-antimicrobial.
Ingxube ye-FRO yaqala ukubonakala kusetshenziswa i-high performance liquid chromatography (HPLC) ukuze ihlukanise, ihlonze futhi ilinganise izingxenye zayo.Ingxube yaphinde yahlaziywa ukuze kutholakale okuqukethwe okuphelele kwe-phenolic (TPC) ukuze kuhlonzwe izinhlanganisela okungenzeka kakhulu zibe nezakhi zokulwa namagciwane.
Isivivinyo sokuqala se-in vitro antimicrobial ngokuhlola ukuzwela kwe-diffusion.Okokuqala, i-CA (phylotype IA1) yakhuliswa ngokulinganayo epuleti le-agar lapho kubekwe khona idiski lephepha le-FRO elifakwe u-10 mm ububanzi.Umsebenzi we-antimicrobial wahlolwa ngokulinganisa ubukhulu besifunda sokuvimbela.
Ukusebenza kwe-FRO ekukhiqizweni kwe-sebum eyenziwe yi-CA kanye nokuhlinzwa kwe-androgen okuhlobene ne-DHT kwahlolwa kusetshenziswa i-Oil Red staining kanye nokuhlaziywa kwe-blot yaseNtshonalanga, ngokulandelanayo.I-FRO yabe isihlolelwa ikhono layo lokunciphisa imiphumela yezinhlobo ze-oxygen esebenzayo (ROS), ezibhekene ne-hyperpigmentation ehlobene nezinduna kanye nezibazi zangemuva kokuhlinzwa, kusetshenziswa i-2′,7′-dichlorofluorescein diacetate (DCF-DA) probe.imbangela.
Imiphumela yokuhlolwa kokusabalalisa kwediski ibonise ukuthi i-20 μL ye-FRO ivimbele ngempumelelo ukukhula kwe-CA futhi yakhiqiza indawo yokuvimbela ebonakalayo engu-13 mm ekuhlanganiseni okungu-100 mg/mL.I-FRO icindezela ngokuphawulekayo ukwanda kokuphuma kwe-sebum okubangelwa yi-SA, ngaleyo ndlela yehlise ijubane noma ihlehlise ukuvela kwezinduna.
I-FRO itholwe inothile ngezinhlanganisela ze-phenolic ezihlanganisa i-gallic acid, i- kaempferol, i-quercetin ne-fisetin.Ingqikithi ye-phenolic compound (TPC) ukugxiliswa okulinganiselwa ku-118.2 mg gallic acid equivalents (GAE) ngegremu ngayinye FRO.
I-FRO inciphise kakhulu ukuvuvukala kwamaselula okubangelwa i-ROS eyenziwe yi-SA kanye nokukhululwa kwe-cytokine.Ukwehliswa kwesikhathi eside kokukhiqizwa kwe-ROS kungase kunciphise i-hyperpigmentation kanye nezibazi.
Nakuba zokwelapha induna yesikhumba zikhona, ngokuvamile ziyabiza futhi zingaba nemiphumela emibi eminingi engadingeki.
Imiphumela ibonisa ukuthi i-FRO inezindawo zokulwa namagciwane ngokumelene ne-CA (ibhaktheriya ebangela izinduna), ngaleyo ndlela ikhombisa ukuthi i-FRO iyindlela engokwemvelo, engenabuthi futhi engabizi kakhulu ekwelashweni kwendabuko kwezinduna.I-FRO iphinde yehlise ukukhiqizwa kwe-sebum nokuvezwa kwehomoni ku-vitro, okubonisa ukusebenza kwayo ekwelapheni nasekuvimbeleni ukuqubuka kwezinduna.
Izivivinyo zomtholampilo ze-FRO zangaphambilini zabonisa ukuthi abantu abasebenzisa i-toner ne-lotion ethuthukisiwe ye-FRO bathole intuthuko enkulu ekunwebeni kwesikhumba namazinga omswakama uma kuqhathaniswa neqembu lokulawula ngemva kwamasonto ayisithupha nje.Nakuba lolu cwaningo aluzange luhlole induna ngaphansi kwezimo ezilawulwa yi-in vitro, imiphumela yamanje isekela lokho abakutholile.
Ihlanganiswe ndawonye, ​​le miphumela isekela ukusetshenziswa kwesikhathi esizayo kwe-FRO ekwelapheni kwezimonyo, okuhlanganisa nokwelashwa kwezinduna kanye nokwenza ngcono impilo yesikhumba iyonke.
Lesi sihloko sahlelwa ngoJuni 9, 2023 ukuze simiselele isithombe esiyinhloko esifaneleke kakhudlwana.
Kufakwe ku: Izindaba Zesayensi Yezokwelapha |Izindaba Zocwaningo Lwezokwelapha |Izindaba Zezifo |Izindaba zemithi
Tags: induna, intsha, androgens, anti-inflammatory, amaseli, chromatography, cytokines, dihydrotestosterone, ukusebenza kahle, fermentation, ufuzo, izici zokukhula, izinwele, amahomoni, hyperpigmentation, in vitro, ukuvuvukala, insulin, phototherapy, liquid chromatography, umoya-mpilo, ukwanda , i-quercetin , i-retinoids, isikhumba, amaseli esikhumba, umbala wesikhumba, i-Western blot
U-Hugo Francisco de Souza ungumbhali wesayensi ozinze e-Bangalore, Karnataka, India.Izithakazelo zakhe zezemfundo zisemkhakheni we-biogeography, i-evolutionary biology kanye ne-herpetology.Njengamanje umatasa neziqu zakhe zobudokotela.ovela eSikhungweni Sesayensi Yezemvelo e-Indian Institute of Science, lapho efunda khona umsuka, ukusatshalaliswa kanye nencazelo yezinyoka zasemanzini.U-Hugo waklonyeliswa nge-DST-INSPIRE Fellowship ngocwaningo lwakhe lobudokotela kanye neNdondo Yegolide evela eNyuvesi yasePondicherry ngezimpumelelo zakhe ezifundweni phakathi nezifundo zakhe ze-Master.Ucwaningo lwakhe lushicilelwe kumajenali abuyekezwe ontanga anomthelela omkhulu okuhlanganisa i-PLOS Neglected Tropical Diseases and Systems Biology.Lapho engasebenzi futhi ebhala, u-Hugo udla amathani e-anime namahlaya, ubhala futhi aqambe umculo ngesiginci se-bass, ahlephule amathrekhi ku-MTB, adlale imidlalo yevidiyo (ukhetha igama elithi “umdlalo”), noma adlale cishe nganoma yini. .ubuchwepheshe.
Francisco de Souza, Hugo.(Julayi 9, 2023).Inhlanganisela eyingqayizivele yezitshalo ezikhishwe inikeza izinzuzo ezinamandla zokulwa nezinduna.Izindaba - Ezokwelapha.Ibuyiswe ngoSepthemba 11, 2023, kusukela ku-https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx.
Francisco de Souza, Hugo."Inhlanganisela eyingqayizivele yezitshalo ezikhishwe ezinezici ezinamandla zokulwa nezinduna."Izindaba - Ezokwelapha.Septhemba 11, 2023.
Francisco de Souza, Hugo."Inhlanganisela eyingqayizivele yezitshalo ezikhishwe ezinezici ezinamandla zokulwa nezinduna."Izindaba - Ezokwelapha.https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx.(Kufinyelelwe ngoSepthemba 11, 2023).
Francisco de Souza, Hugo.2023. Inhlanganisela eyingqayizivele yezitshalo ezikhishwe ezinezici ezinamandla zokulwa nezinduna.I-News Medical, ifinyelelwe ngoSepthemba 11, 2023, https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx.
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