Sisebenzisa amakhukhi ukuthuthukisa ulwazi lwakho. Ngokuqhubeka uphequlula le sayithi, uyavuma ukusebenzisa kwethu amakhukhi. Ulwazi olwengeziwe.
Ngokuchofoza okuthi “Vumela Konke”, uyavuma ukuthi amakhukhi agcinwe kudivayisi yakho ukuze kuthuthukiswe ukuzulazula kwesayithi, kuhlaziywe ukusetshenziswa kwesayithi, futhi kusekelwe ekuhlinzekeni kwethu kokuqukethwe kwesayensi okufinyelela kalula nokungena mahhala. Ulwazi olwengeziwe.
Ocwaningweni lwakamuva olushicilelwe kumagazini i-Pharmaceutics, abacwaningi bathole ukusebenza kahle kwamakhemikhali abizwa ngokuthi i-FRO ekulweni nesifo se-acne.
Ukuhlolwa kwe-antimicrobial kanye nokuhlaziywa kwe-in vitro kubonise ukuthi i-FRO inemiphumela ebalulekile yokulwa namagciwane kanye nokuvuvukala ngokumelene ne-Dermatobacillus Acnes (CA), igciwane elibangela i-acne. Le miphumela ikhombisa ukusetshenziswa kwayo okuphephile nokwemvelo ekwelapheni i-acne, okusekela ukusetshenziswa kwezinye izindlela ezingezona ezinobuthi nezingabizi kakhulu kunemithi yamanje ye-acne.
Ucwaningo: Ukusebenza kahle kwe-FRO ekubangeleni i-acne vulgaris. Isithombe sithathwe ku: Steve Jungs/Shutterstock.com
I-acne vulgaris, eyaziwa ngokuthi ama-pimples, iyisifo sesikhumba esivamile esibangelwa ama-follicle ezinwele avinjiwe ane-sebum kanye namaseli esikhumba afile. I-acne ithinta abantu abangaphezu kwamaphesenti angu-80 abasebasha futhi, nakuba ingeyona ingozi, ingabangela ukucindezeleka kwengqondo futhi, ezimweni ezimbi kakhulu, ingabangela ukuguquka kwesikhumba okungapheli kanye nezibazi.
I-acne ibangelwa ukusebenzisana kwezici zofuzo kanye nezemvelo, okuvame ukubangelwa izinguquko zamahomoni ezihambisana nokuthomba ngesikhathi sokuthomba. Lokhu kungalingani kwamahomoni kwandisa ukukhiqizwa kwe-sebum futhi kwandisa umsebenzi we-insulin growth factor 1 (IGF-1) kanye ne-dihydrotestosterone (DHT).
Ukwanda kokukhiqizwa kwe-sebum kubhekwa njengesigaba sokuqala ekukhuleni kwe-acne, njengoba ama-follicle ezinwele agcwele i-sebum aqukethe inani elikhulu lama-microorganisms afana ne-SA. I-SA iyinto yemvelo yesikhumba; nokho, ukwanda okukhulu kwe-phylotype yayo IA1 kubangela ukuvuvukala kanye nokushintshashintsha kwemibala yama-follicle ezinwele ngama-papules abonakala ngaphandle.
Kunezindlela ezahlukene zokwelapha izimonyo zezinduna, njenge-retinoids kanye nezidakamizwa zamagciwane, ezisetshenziswa kanye nama-chemical peels, ukwelashwa nge-laser/light, kanye nezidakamizwa zama-hormone. Kodwa-ke, lezi zindlela zokwelapha zibiza kakhulu futhi zihlotshaniswa nemiphumela emibi.
Izifundo zangaphambilini zihlole izingcezu zamakhambi njengendlela yemvelo engabizi kakhulu esikhundleni salezi zindlela zokwelapha. Njengenye indlela, kuye kwafundwa izingcezu ze-Rhus vulgaris (RV). Kodwa-ke, ukusetshenziswa kwayo kunqunyelwe yi-urushiol, ingxenye ebalulekile ye-allergen yalesi sihlahla.
I-FRO iyifomula yamakhambi equkethe izingcezu ezivutshiwe ze-RV (FRV) kanye ne-Japanese mangosteen (OJ) ngesilinganiso esingu-1:1. Ukusebenza kahle kwale fomula kuhlolwe kusetshenziswa izivivinyo ze-in vitro kanye nezakhiwo zokulwa namagciwane.
Ingxube ye-FRO yaqala ukuchazwa kusetshenziswa i-high performance liquid chromatography (HPLC) ukuze ihlukanise, ihlonze futhi ilinganise izingxenye zayo. Ingxube yahlaziywa kabanzi ukuze kutholakale okuqukethwe okuphelele kwe-phenolic (TPC) ukuze kutholakale amakhemikhali okungenzeka kakhulu abe nezakhiwo zokulwa namagciwane.
Ukuhlolwa kokuqala kwe-in vitro antimicrobial ngokuhlola ukuzwela kokusabalala kwediski. Okokuqala, i-CA (phylotype IA1) yakhuliswa ngokulinganayo epuletini le-agar lapho kwabekwa khona idiski yephepha lokuhlunga elifakwe i-FRO elingu-10 mm ububanzi. Umsebenzi we-antimicrobial wahlolwa ngokulinganisa ubukhulu bendawo yokuvimbela.
Ukusebenza kahle kwe-FRO ekukhiqizweni kwe-sebum okubangelwa yi-CA kanye nokwanda kwe-androgen okuhlobene ne-DHT kuhlolwe kusetshenziswa i-Oil Red staining kanye nokuhlaziywa kwe-Western blot, ngokulandelana. I-FRO yabe isihlolwa ikhono layo lokunciphisa imiphumela yezinhlobo ze-oxygen ezisabelayo (i-ROS), ezibangela i-acne-associated hyperpigmentation kanye nezibazi zangemva kokuhlinzwa, kusetshenziswa i-2′,7′-dichlorofluorescein diacetate (DCF-DA) probe.
Imiphumela yokuhlolwa kokusabalala kwediski ibonise ukuthi ama-μL angu-20 e-FRO avimbele ngempumelelo ukukhula kwe-CA futhi akhiqize indawo ebonakalayo yokuvimbela engu-13 mm ekugxilweni okungu-100 mg/mL. I-FRO icindezela kakhulu ukwanda kokukhiqizwa kwe-sebum okubangelwa yi-SA, ngaleyo ndlela yehlisa noma ibuyisele emuva ukwenzeka kwe-acne.
Kutholakale ukuthi i-FRO icebile ngama-phenolic compounds afaka phakathi i-gallic acid, i-kaempferol, i-quercetin kanye ne-fisetin. Ukuhlushwa kwe-phenolic compound (TPC) okulinganiselwe ku-118.2 mg gallic acid equivalents (GAE) ngegremu ngayinye i-FRO.
I-FRO inciphise kakhulu ukuvuvukala kwamangqamuzana okubangelwa yi-SA-induced ROS kanye nokukhishwa kwe-cytokine. Ukunciphisa isikhathi eside ekukhiqizweni kwe-ROS kunganciphisa i-hyperpigmentation kanye nezibazi.
Nakuba kukhona ukwelashwa kwesikhumba kwama-acne, ngokuvamile kuyabiza futhi kungaba nemiphumela emibi eminingi engafuneki.
Imiphumela ikhombisa ukuthi i-FRO inezakhiwo zokulwa namagciwane ngokumelene ne-CA (amagciwane abangela induna), ngaleyo ndlela ikhombisa ukuthi i-FRO iyindlela yemvelo, engenabo ubuthi futhi engabizi kakhulu yokwelapha induna yendabuko. I-FRO iphinde yehlise ukukhiqizwa kwe-sebum kanye nokuvezwa kwama-hormone ngaphakathi kwe-vitro, ikhombisa ukusebenza kwayo ekwelapheni nasekuvimbeleni ukuqubuka kwenduna.
Izivivinyo zemitholampilo zangaphambilini ze-FRO zibonise ukuthi abantu abasebenzisa i-toner ne-lotion ethuthukisiwe ye-FRO bahlangabezane nokuthuthuka okukhulu emazingeni okuqina kwesikhumba kanye nomswakama uma kuqhathaniswa neqembu lokulawula ngemva kwamasonto ayisithupha nje. Nakuba lolu cwaningo lungazange luhlole i-acne ngaphansi kwezimo ezilawulwayo ze-in vitro, imiphumela yamanje isekela okutholakele kwabo.
Uma kuhlanganiswa, le miphumela isekela ukusetshenziswa kwe-FRO esikhathini esizayo ekwelashweni kwezimonyo, okuhlanganisa ukwelashwa kwezinduna kanye nokuthuthukisa impilo yesikhumba iyonke.
Lesi sihloko sahlelwa ngoJuni 9, 2023 ukuze kufakwe isithombe esiyinhloko esikhundleni saso esifaneleka kakhulu.
Kuthunyelwe ku: Izindaba Zesayensi Yezokwelapha | Izindaba Zocwaningo Lwezokwelapha | Izindaba Zezifo | Izindaba Zemithi
Amathegi: induna, intsha, ama-androgens, okulwa nokuvuvukala, amaseli, i-chromatography, ama-cytokine, i-dihydrotestosterone, ukusebenza kahle, ukuvutshelwa, izakhi zofuzo, izici zokukhula, izinwele, ama-hormone, i-hyperpigmentation, i-in vitro, ukuvuvukala, i-insulin, i-phototherapy, i-chromatography yoketshezi, i-oxygen, ukwanda, i-quercetin, ama-retinoids, isikhumba, amaseli esikhumba, i-pigmentation yesikhumba, i-Western blot
UHugo Francisco de Souza ungumlobi wesayensi oseBangalore, eKarnataka, eNdiya. Izintshisekelo zakhe kwezemfundo zisemkhakheni we-biogeography, i-biology yokuziphendukela kwemvelo kanye ne-herpetology. Njengamanje usebenza ku-dissertation yakhe yobudokotela, evela e-Center for Environmental Sciences e-Indian Institute of Science, lapho efunda khona imvelaphi, ukusatshalaliswa kanye nokuchazwa kwezinyoka zasemanzini. UHugo wanikezwa i-DST-INSPIRE Fellowship ngocwaningo lwakhe lobudokotela kanye ne-Gold Medal evela ePondicherry University ngenxa yempumelelo yakhe yezemfundo ngesikhathi sezifundo zakhe ze-Master's. Ucwaningo lwakhe lushicilelwe emaphephandabeni abukezwe ontanga anomthelela omkhulu kufaka phakathi i-PLOS Neglected Tropical Diseases kanye ne-Systems Biology. Uma engasebenzi futhi ebhala, uHugo udla i-anime eningi namahlaya, ubhala futhi aqambe umculo ku-bass guitar, usika amathrekhi ku-MTB, udlala imidlalo yevidiyo (ukhetha igama elithi "umdlalo"), noma ashintshe cishe noma yini. ubuchwepheshe.
UFrancisco de Souza, uHugo. (Julayi 9, 2023). Ingxube eyingqayizivele yezingcezu zezitshalo inikeza izinzuzo ezinamandla zokulwa nama-acne. Izindaba - Ezokwelapha. Kuthathwe ngoSepthemba 11, 2023, ku-https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx.
UFrancisco de Souza, uHugo. “Inhlanganisela eyingqayizivele yezingcezu zezitshalo ezinezakhiwo ezinamandla zokulwa nama-acne.” Izindaba – Ezokwelapha. Septhemba 11, 2023.
UFrancisco de Souza, uHugo. “Inhlanganisela eyingqayizivele yezingcezu zezitshalo ezinezakhiwo ezinamandla zokulwa nama-acne.” Izindaba – Ezokwelapha. https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx. (Kufinyelelwe ngoSepthemba 11, 2023).
UFrancisco de Souza, uHugo. 2023. Ingxube eyingqayizivele yezingcezu zezitshalo ezinezakhiwo ezinamandla zokulwa nama-acne. I-News Medical, efinyelelwe ngoSepthemba 11, 2023, https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx.
Izithombe ezisetshenziswe kulesi "sifinyezo" azihlobene nalolu cwaningo futhi ziyadukisa ngokuphelele ngokusikisela ukuthi lolu cwaningo luhilela ukuhlolwa kubantu. Kufanele lususwe ngokushesha.
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