I-Arachidonic acid (ARA), i-docosahexaenoic acid (DHA) kanye ne-eicosapentaenoic acid (EPA) ngamaketanga amade e-polyunsaturated fatty acids (LCPUFA). Ama-carotenoids, okuhlanganisa i-lutein ne-zeaxanthin (LZ), atholakala kakhulu emifino eluhlaza.
I-ARA ne-DHA ziningi ebuchosheni futhi ziyizingxenye eziyinhloko zama-phospholipids. Ucwaningo luye lwabonisa ukuthi ukugcwalisa ngemithamo ephezulu ye-DHA ne-EPA kungathuthukisa ukusebenza kwenkumbulo kubantu abadala.
Ngaphezu kwalokho, i-LZ, ingxenye yobuchopho e-antioxidant, kuye kwabikwa ukuthi inomphumela wokuvikela kumangqamuzana ezinzwa, ngaleyo ndlela ithinte ukusebenza kwengqondo. Kodwa-ke, ukusebenza kahle kwe-lutein ne-zeaxanthin ekusebenzeni kwenkumbulo akucaci ngenxa yemiphumela engqubuzanayo evela ezifundweni zokungenelela zangaphambilini.
Ngokusekelwe eqinisweni lokuthi i-ARA, i-DHA, i-EPA, i-L ne-Z (i-LCPUFA + LZ) ikhona ebuchosheni, kanye neminye imibiko yokusebenza okuthuthukisiwe kwenkumbulo, ababhali bocwaningo lwamanje baphakamise ukuthi inhlanganisela yalezi zinto ingase ithuthuke. inkumbulo. ukusebenza ebuchosheni. abantu abadala abanempilo.
Abacwaningi baseJapane benza ucwaningo lwamaviki angu-24, olungahleliwe, oluyimpumputhe kabili, olulawulwa yi-placebo, oluhambisana nemiphumela ye-LCPUFA + LH ekusebenzeni kwenkumbulo kubantu asebekhulile baseJapane abanempilo abanezinkinga zenkumbulo kodwa abangenakho ukuwohloka komqondo.
Abatholanga umehluko obalulekile phakathi kwamaqembu. Kodwa-ke, ekuhlaziyweni okuhlangene kweqembu labahlanganyeli abanokuncipha kwengqondo, ukuthuthukiswa okuphawulekayo kwabonwa.
Lo mbiko uphetha ngokuthi: “Lolu cwaningo lubonisa ngokokuqala ngqá ukuthi inhlanganisela ye-LCPUFA ne-LZ ingathuthukisa ukusebenza kwenkumbulo kubantu abadala baseJapane abaphile kahle abanenkinga yokuqonda kodwa ngaphandle kokuwohloka komqondo.” 'umbhalo ad1′); });
Isamba sabahlanganyeli be-120 abavela e-Tokyo nasezindaweni ezizungezile zahlelwa ngokungahleliwe zaba amaqembu amathathu: (1) iqembu le-placebo elithola i-placebo njengesengezo sokudla; (2) iqembu le-placebo elithola i-placebo njengesengezo sokudla; (2)). Iqembu le-LCPUFA+X elithole isengezo sokudla esihlanganisa i-LCPUFA (equkethe i-120 mg ARA, 300 mg DHA kanye ne-100 mg EPA ngosuku) ne-Compound X (ayiboniswanga njengoba le nhlanganisela bekungeyona isihloko salolu cwaningo) ) (3) LCPUFA +LH iqembu elithola isengezo sokudla esihlanganisa i-LCPUFA (120mg ARA, 300mg DHA kanye ne-100mg EPA ngosuku) kuhlanganiswe ne-LH (10mg lutein kanye ne-2mg zeaxanthin ngosuku).
Ukudla okuhlolwayo kanye nezinsiza zalolu cwaningo kunikezwe i-Suntory Health Co., Ltd., edayisa ukudla kwezempilo okuqukethe i-LCPUFA.
I-Wechsler Logical Memory Scale II ebuyekeziwe (WMS-R LM II) kanye ne-Montreal Cognitive Test ngesi-Japanese (MoCA-J) yasetshenziselwa ukuhlola.
Iminyaka yobudala, ubulili, kanye nemfundo kurekhodwe njengezici zabahlanganyeli. Amasampula egazi aqoqwe ekuqaleni, amaviki e-12 ne-24 ku-fatty acid kanye nokuhlaziywa kwe-LZ.
Ukuhlolwa kwe-Neuropsychological kwenziwa futhi ukuthathwa kwe-fatty acid yokudla kwalinganiswa ekuqaleni, kumaviki angu-12 nama-24. Umhlanganyeli ngamunye ugcwalise idayari, aqophe ukudla okwengeziwe futhi ahlole izinguquko ezinkulu zokuphila.
Okutholakele kubonise ukuthi i-LCPUFA + LZ yayingenawo umthelela obalulekile ekusebenzeni kwenkumbulo kubantu baseJapane asebekhulile abanempilo abanezinkinga zenkumbulo, kodwa isengezo sithuthukise ukusebenza kwenkumbulo kubahlanganyeli abanokuncipha kwengqondo.
Ababhali bathi izifundo zokungenelela zesikhathi esizayo ezisekelwe olwazini oluningiliziwe lwesisekelo sokusebenza kwengqondo sabahlanganyeli zizosiza ukwenza izinqumo ezifanele mayelana nomphumela wokungenelela emsebenzini wenkumbulo.
"Umthelela we-long-chain polyunsaturated fatty acids kuhlanganiswe ne-lutein ne-zeaxanthin kwinkumbulo ye-episodic kubantu asebekhulile abanempilo"
Sueyasu, T., Yasumoto, K., Tokuda, H., Kaneda, Y.;
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