I-Arachidonic acid (ARA), i-docosahexaenoic acid (DHA) kanye ne-eicosapentaenoic acid (EPA) yi-long chain polyunsaturated fatty acids (LCPUFA). Ama-Carotenoid, afaka phakathi i-lutein ne-zeaxanthin (LZ), atholakala kakhulu emifinweni eluhlaza.
I-ARA ne-DHA ziningi ebuchosheni futhi ziyizingxenye eziyinhloko zama-phospholipid. Izifundo zibonise ukuthi ukwengeza ngemithamo ephezulu ye-DHA ne-EPA kungathuthukisa ukusebenza kwenkumbulo kubantu abadala.
Ngaphezu kwalokho, i-LZ, ingxenye yobuchopho elwa nama-antioxidant, ibikwe ukuthi inomphumela wokuvikela amangqamuzana ezinzwa, ngaleyo ndlela ithinta ukusebenza kwengqondo. Kodwa-ke, ukusebenza kahle kwe-lutein ne-zeaxanthin emsebenzini wenkumbulo akucaci ngenxa yemiphumela ephikisanayo evela ezifundweni zokungenelela zangaphambilini.
Ngokusekelwe eqinisweni lokuthi i-ARA, i-DHA, i-EPA, i-L kanye ne-Z (i-LCPUFA + i-LZ) zikhona ebuchosheni, kanye neminye imibiko yokusebenza kwenkumbulo okuthuthukisiwe, abalobi bocwaningo lwamanje basikisela ukuthi ukuhlanganiswa kwalezi zinto kungathuthukisa inkumbulo. ukusebenza kwengqondo. abantu asebekhulile abanempilo.
Abacwaningi baseJapan benze ucwaningo lweqembu lwamasonto angama-24, olungahleliwe, olungaboni kabili, olulawulwa yi-placebo, oluhambisanayo lwemiphumela ye-LCPUFA + LH ekusebenzeni kwenkumbulo kubantu asebekhulile baseJapan abanempilo abanezinkinga zenkumbulo kodwa abangenayo i-dementia.
Abatholanga mehluko obalulekile phakathi kwamaqembu. Kodwa-ke, ekuhlaziyweni okuhlangene kweqembu labahlanganyeli abanokwehla kwengqondo, kwabonakala ukuthuthuka okukhulu.
Umbiko uphetha ngokuthi: “Lolu cwaningo lubonisa okokuqala ukuthi inhlanganisela ye-LCPUFA ne-LZ ingathuthukisa ukusebenza kwenkumbulo kubantu abadala baseJapane abanempilo abanokwehla kwengqondo kodwa abangenayo i-dementia.” 'text ad1′); });
Inani labahlanganyeli abangu-120 abavela eTokyo nasezindaweni ezizungezile bahlukaniswe ngamaqembu amathathu: (1) iqembu le-placebo elithola i-placebo njengesithasiselo sokudla; ​​(2) iqembu le-placebo elithola i-placebo njengesithasiselo sokudla; ​​(2)). Iqembu le-LCPUFA+X elathola isithasiselo sokudla esiqukethe i-LCPUFA (equkethe i-120 mg ye-ARA, i-300 mg ye-DHA kanye ne-100 mg ye-EPA ngosuku) nge-Compound X (ayiboniswanga njengoba le nhlanganisela yayingeyona isihloko salolu cwaningo) ) (3) Iqembu le-LCPUFA+LH elithola isithasiselo sokudla esiqukethe i-LCPUFA (120mg ye-ARA, 300mg ye-DHA kanye ne-100mg ye-EPA ngosuku) kuhlanganiswe ne-LH (10mg ye-lutein kanye ne-2mg ye-zeaxanthin ngosuku).
Ukudla okuhloliwe kanye nezinto ezidingekayo zalolu cwaningo kuhlinzekwe yiSuntory Health Co., Ltd., ethengisa ukudla okunempilo okuqukethe i-LCPUFA.
I-Wechsler Logical Memory Scale II (WMS-R LM II) ebuyekeziwe kanye ne-Montreal Cognitive Test ngesiJapane (MoCA-J) zasetshenziswa ekuhlolweni.
Ubudala, ubulili, kanye nemfundo kwaqoshwa njengezimpawu zabahlanganyeli. Amasampula egazi aqoqwa ekuqaleni, amasonto 12 no-24 ukuze kuhlolwe i-fatty acid kanye ne-LZ.
Kwenziwa ukuhlolwa kwe-neuropsychological futhi ukudla okunamafutha acid kwalinganiswa ekuqaleni, emavikini ayi-12 nama-24. Umhlanganyeli ngamunye wagcwalisa idayari, eqopha ukudla okwengeziwe futhi ehlola izinguquko ezinkulu endleleni yokuphila.
Okutholakele kukhombisile ukuthi i-LCPUFA + LZ ayinawo umthelela omkhulu ekusebenzeni kwenkumbulo kubantu asebekhulile baseJapan abanempilo abanezinkinga zenkumbulo, kodwa lesi sithasiselo sithuthukise ukusebenza kwenkumbulo kubahlanganyeli abanokwehla kwengqondo.
Abalobi bathi izifundo zokungenelela zesikhathi esizayo ezisekelwe olwazini oluningiliziwe lokusebenza kwengqondo okuyisisekelo kwabahlanganyeli kuzosiza ekwenzeni izinqumo ezifanele mayelana nomphumela wokungenelela emsebenzini wenkumbulo.
"Umphumela wama-fatty acid e-polyunsaturated ahlanganiswe ne-lutein ne-zeaxanthin kwimemori yeziqephu kubantu asebekhulile abanempilo"
Sueyasu, T., Yasumoto, K., Tokuda, H., Kaneda, Y.;
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