Ulwazi Olwengeziwe Nge-Aframomum Melegueta Extract 6-Paradol

1. I-Abstract ye-Aframomum Melegueta

IAframomum Melegueta, odabuka eNtshonalanga Afrika, unephunga le-cardamom kanye ne-peppery flavour. Wawusetshenziswa kakhulu esikhundleni lapho upelepele wawuyindlala eYurophu ekhulwini le-13, futhi wawubizwa ngokuthi “inzalo yezulu” ngoba wawubhekwa njengomusa ovela ezulwini.

I-Aframomum Melegueta inamagama ahlukene njengezinhlamvu zepharadesi, i-Atare (ngesiYoruba), i-chitta (Hausa), noma upelepele waseGuinea, iyimbewu eyodwa enamandla amaningi okuphulukisa futhi izinzuzo zayo esintwini zibonakala zingapheli.

I-Aframomum melegueta (Izinhlamvu ZePharadesi) isetshenziselwe ukwelapha izifo ezithathelwanayo ezifana nezifo zomgudu womchamo ezibangelwa i-Escherichia coli, i-Klebsiella pneumoniae, i-Enterococcus faecalis, i-Staphylococcus saprophyticus, i-Proteus mirabilis, i-methicillin emelana ne-Staphyloppscus, i-methicillin ephikisana ne-Staphyloppscus, i-methicillin ephikisana ne-Staphyloppscoccus, i-Staphylococcus saprophyticus. Ibonisa isithembiso esithile ekulawuleni ukukhuluphala kwamafutha ngemithamo engasebenziseka emikhiqizweni yokudla kanye nengxube yemithi.

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2.Indawo Yokusabalalisa

Aframomum Melegueta(I-Paradise Pepper), ogama layo langempela lingu-African Cardamom, owaziwa nangokuthi u-Peppercorn, i-Guinea Pepper, i-Melegueta Pepper, i-Paradise Pepper, noma i-Alligator Pepper, isitshalo esingapheli somndeni we-Zingiberaceae. Indabuko yamaxhaphozi asogwini lwaseNtshonalanga Afrika. Ivula izimbali ezinsomi, ezimise okwecilongo, amabhere angama-5-7 cm ubude futhi iqukethe imbewu ebomvu ngokubomvu. I-Peppery, futhi ngoba yaba indawo yokuqala kapelepele. Manje sekuyinsakavukela ukusetshenziswa kwangaphakathi e-Afrika. Esinye isinongo sikaSilk Road esinyamalele ekudleni kwesimanje kwase-Eurasia, kodwa sisasetshenziswa ezingxenyeni zaseNtshonalanga naseNyakatho Afrika, futhi siyisitshalo esibalulekile semali ezingxenyeni ezithile ze-Ethiopia. I-African cardamom, edabuka ezindaweni ezisogwini entshonalanga ye-Afrika, kubonakala sengathi yayisetshenziswa eduze neGhana yanamuhla ekuqaleni futhi kamuva yathunyelwa ezindaweni ezithile zamachweba empumalanga ye-Afrika noma ngasogwini lweMedithera ukuze ihwebe ngoSilk Road. Isinongo, okwakuwulaka olukhulu ekuphekeni kwaseYurophu ngesikhathi seRenaissance yakuqala, sashabalala kancane kancane etafuleni ngekhulu leshumi nesishiyagalombili sabe sesinyamalala ezimakethe zaseYurophu, kwathathelwa indawo i-cardamom nezinye izinongo ezithunyelwa kwamanye amazwe zisuka e-Asia emhlabeni jikelele.

3. Ukwethulwa kwe-6-Paradol

I-Paradol, i-metabolite engaphuzi ye-shogaol ngokunciphisa i-enzymatic, yaziwa ukuthi inemisebenzi yokulwa nokuvuvukala. Okutholakele kwamanje kwe-in vitro kukhombisa ukuthi izakhiwo ezivimbayo ze-6-paradol ekwelapheni i-neuroinflammation ku-microglia zihambisana namandla okwelapha e-vivo e-cerebral ischemia. Ukusebenza kahle kwe-neuroprotective ye-6-paradol ku-cerebral ischemia nakho kunokusetshenziswa okungenzeka ekwelapheni ezinye iziyaluyalu ze-CNS lapho i-neuroinflammation iyisici se-pathological. Ngaphezu kwalokho, uma i-6-paradol iboniswa ukuthi iyasebenza kwezinye izifo ze-CNS, impahla yayo engeyona i-pungent inenzuzo yemiphumela emibi embalwa esiswini, okusho ukuthi ingathathwa isikhathi eside, ngokungafani ne-ginger noma izingxenye ze-ginger. cishe 6-shogaol.

6-paradoliyi-antimalarial enamandla kakhulu futhi iyingxenye enkulu yeZookwesibilii-metabolite pool.

I-6-Paradol (igama le-IUPAC [1-(4-hydroxy-3-methoxyphenyl) decan-3-one]) iyinhlanganisela ye-phenolic ebabayo etholakala ezitshalweni zomndeni we-Zingiberaceae, njengejinja kanye nezinhlamvu zepharadesi (Aframomum meleguetanoma upelepele wengwenya). Njengoba kushiwo kwenye indawo, izifundo ezimbalwa zibike imisebenzi ye-antioxidant, anti-inflammatory, cytotoxic, anti-hyperlipidaemic, hypoglycaemic, kanye ne-antitumour yezinhlanganisela ezahlukene ze-paradol kumamodeli ezilwane ahlukahlukene.

4. Umsebenzi Womkhiqizo

1. I-Aframomum melegueta extract ingasetshenziswa njenge-Spice kanye ne-agent yokunambitha;

2. I-Aframomum melegueta extract ingasetshenziswa njengesikhuthazi esinephunga elimnandi;ekwelapheni ukukhwehlela kanye ne-bronchitis;i-anti-rheumatic;i-dyspepsia;

3. Ukukhishwa kwe-Aframomum melegueta kutholakale ukukhuthaza ukulahlekelwa kwesisindo ngokukhuthaza umzimba womzimba osheshayo;

4. Ukukhishwa kwe-Aframomum melegueta kungakhuphula amandla ocansi njenge-aphrodisiac.

 

Izithenjwa:https://www.zhitiquan.com

I-Aframomum Melegueta (Grains of Paradise)——Oludare Temitope Osuntokun

https://doi.org/10.1371/journal.pone.0120203

https://doi.org/10.1016/j.phyplu.2021.100208

 

NgobaAframomum Melegueta, sicela usithinte. Sikulindile la noma nini!!!

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Isikhathi sokuthumela: Jan-04-2023