Ocwaningweni olusha, abacwaningi bathola ukuthi umuthi omusha osuselwe engxenyeni yembewu yamagilebhisi ekhishwe unganweba ngempumelelo iminyaka yokuphila nempilo yamagundane.
Ucwaningo, olushicilelwe kujenali ye-Nature Metabolism, lubeka isisekelo sezifundo ezengeziwe zomtholampilo ukuze kutholwe ukuthi le miphumela ingaphindaphindeka yini kubantu.
Ukuguga kuyisici esiyinhloko engozini yezifo eziningi ezingapheli. Ososayensi bakholelwa ukuthi lokhu ngokwengxenye kungenxa yokuguga kwamangqamuzana. Lokhu kwenzeka lapho amaseli engasakwazi ukwenza imisebenzi yawo yezinto eziphilayo emzimbeni.
Eminyakeni yamuva, abacwaningi bathole ikilasi lezidakamizwa ezibizwa ngokuthi ama-senolytics. Le mithi ingacekela phansi amangqamuzana abomvu egazi kulabhorethri kanye namamodeli ezilwane, okungase kunciphise izehlakalo zezifo ezingamahlalakhona eziphakama njengoba sikhula futhi siphila isikhathi eside.
Kulolu cwaningo, ososayensi bathole i-senolytic entsha etholakala engxenyeni yembewu yamagilebhisi ekhishwe ebizwa ngokuthi i-proanthocyanidin C1 (PCC1).
Ngokusekelwe kudatha yangaphambilini, i-PCC1 kulindeleke ukuthi ivimbele ukusebenza kwamaseli e-senescent ekugxiliseni okuphansi futhi ibulale ngokukhetha amaseli e-senescent ezindaweni eziphezulu.
Ocwaningweni lokuqala, badalule amagundane kumithamo emincane eyingozi yemisebe ukuze bahehe ukubukeka kwamaselula. Iqembu elilodwa lamagundane labe selithola i-PCC1, kwathi elinye lathola imoto ethwele i-PCC1.
Abacwaningi bathola ukuthi ngemva kokuba amagundane evezwe emisebeni, ahlakulela izici zomzimba ezingavamile, okuhlanganisa nenani elikhulu lezinwele ezimpunga.
Ukwelashwa kwamagundane nge-PCC1 kuziguqule kakhulu lezi zici. Amagundane anikezwe i-PCC1 nawo abe namaseli e-senescent ambalwa nama-biomarker ahlobene namaseli e-senescent.
Ekugcineni, amagundane afakwe imisebe ayenokusebenza okuncane namandla emisipha. Kodwa-ke, isimo sashintsha kumagundane anikezwe i-PCC1, futhi ayenamazinga aphezulu okusinda.
Ocwaningweni lwesibili, abacwaningi bajove amagundane aguga nge-PCC1 noma imoto njalo emavikini amabili izinyanga ezine.
Ithimba lithole izinombolo ezinkulu zamangqamuzana ezinzwa ezinso, isibindi, amaphaphu kanye nendlala yamagundane amadala. Nokho, ukwelashwa nge-PCC1 kwashintsha isimo.
Amagundane aphathwe nge-PCC1 aphinde abonise ukuthuthukiswa kwamandla okubamba, isivinini esikhulu sokuhamba, ukukhuthazela okulenga, ukukhuthazela kwe-treadmill, izinga lomsebenzi wansuku zonke, nokulinganisela uma kuqhathaniswa namagundane athole imoto yodwa.
Ocwaningweni lwesithathu, abacwaningi babheke amagundane amadala kakhulu ukuze babone ukuthi i-PCC1 iyithinte kanjani impilo yabo.
Bathole ukuthi amagundane alashwe nge-PCC1 aphila ngokwesilinganiso esingu-9.4% isikhathi eside kunamagundane aphathwa ngemoto.
Ngaphezu kwalokho, naphezu kokuphila isikhathi eside, amagundane alashwe nge-PCC1 awazange abonise noma yikuphi ukugula okuphezulu okuhlobene neminyaka uma kuqhathaniswa namagundane alashwe ngemoto.
Efingqa lokho okutholwe, umbhali ohambisanayo, uSolwazi Sun Yu we-Shanghai Institute of Nutrition and Health e-China kanye nozakwabo wathi: “Ngalokhu sinikeza ubufakazi besimiso sokuthi [i-PCC1] inamandla okubambezela ngokuphawulekayo ukungasebenzi okuhlobene nobudala ngisho nalapho kuthathwa.” ngokuhamba kwesikhathi empilweni, inamandla amakhulu okunciphisa izifo ezihlobene neminyaka futhi ithuthukise imiphumela yezempilo, ngaleyo ndlela ivule izindlela ezintsha zemithi yesikhathi esizayo yezokwelapha ukuthuthukisa impilo nokuphila isikhathi eside. "
UDkt James Brown, oyilungu le-Aston Center for Healthy Aging e-Birmingham, e-UK, utshele i-Medical News Today ukuthi okutholakele kunikeza ubufakazi obengeziwe bezinzuzo ezingaba khona zemithi elwa nokuguga. UDkt. Brown akazange ahlanganyele ocwaningweni lwakamuva.
"I-Senolytics iyisigaba esisha sezinto ezilwa nokuguga ezivame ukutholakala emvelweni. Lolu cwaningo lubonisa ukuthi i-PCC1, kanye nezinhlanganisela ezifana ne-quercetin ne-fisetin, iyakwazi ukubulala amangqamuzana e-senescent ngokukhetha kuyilapho ivumela amaseli amancane, anempilo ukuthi alondoloze ukusebenza kahle. ”
"Lolu cwaningo, njengezinye izifundo kule ndawo, luhlole imiphumela yalezi zinhlanganisela kumagundane nezinye izinto eziphilayo eziphansi, ngakho-ke umsebenzi omningi osasele ngaphambi kokuthi kutholakale imiphumela yokulwa nokuguga yalezi zinhlanganisela kubantu."
"I-Senolytics ngokuqinisekile ibambe isithembiso sokuba yizidakamizwa ezihamba phambili zokulwa nokuguga ekuthuthukisweni," kusho uDkt. Brown.
USolwazi Ilaria Bellantuono, uprofesa wokuguga kwamathambo e-University of Sheffield e-UK, uvumile engxoxweni ne-MNT ukuthi umbuzo obalulekile ukuthi lokhu okutholakele kungaphindaphindwa yini kubantu. USolwazi Bellantuono naye akazange abambe iqhaza kulolu cwaningo.
"Lolu cwaningo lwengeza ubufakazi bokuthi ukukhomba amangqamuzana egazi ngezidakamizwa eziwabulala ngokukhethekile, ezibizwa ngokuthi 'i-senolytics,' kungathuthukisa ukusebenza komzimba njengoba sikhula futhi kwenze izidakamizwa ze-chemotherapy ziphumelele kakhulu kumdlavuza."
“Kubalulekile ukuqaphela ukuthi yonke imininingwane ekule ndawo ivela ezilwaneni—kulokhu, amamodeli amagundane. Inselele yangempela ukuhlola ukuthi le mithi isebenza ngokulinganayo yini [kubantu]. Ayikho idatha etholakalayo ngalesi sikhathi.” , futhi izivivinyo zomtholampilo zisanda kuqala,” kusho uSolwazi Bellantuono.
UDkt David Clancy, ovela ku-Faculty of Biomedicine and Biological Sciences eLancaster University e-UK, utshele i-MNT ukuthi amazinga omthamo angaba yinkinga uma kusetshenziswa imiphumela kubantu. UDkt. Clancy akazange ahlanganyele ocwaningweni lwakamuva.
“Imithamo enikezwa amagundane ivamise ukuba mikhulu kakhulu uma iqhathaniswa nalokho abantu abangakubekezelela. Imithamo efanelekile ye-PCC1 kubantu ingase ibangele ubuthi. Izifundo zamagundane zingaba nolwazi; isibindi sabo sibonakala sigaya izidakamizwa njengesibindi somuntu kunesibindi segundane. ”
UDkt Richard Siow, umqondisi wocwaningo lokuguga eKing's College London, uphinde watshela i-MNT ukuthi ucwaningo lwezilwane okungezona ezomuntu kungenzeka lungaholeli emiphumeleni emihle yomtholampilo kubantu. UDkt. Siow naye akazange abambe iqhaza ocwaningweni.
“Angilingani ngaso sonke isikhathi ukutholakala kwamagundane, izikelemu nezimpukane nabantu, ngoba iqiniso elimsulwa wukuthi sinama-akhawunti asebhange kanti abanawo. Sinazo izikhwama zemali, kodwa azinazo. Sinazo nezinye izinto ekuphileni. Gcizelela ukuthi izilwane Asinazo: ukudla, ukuxhumana, umsebenzi, izingcingo ze-Zoom. Ngiqinisekile ukuthi amagundane angagcizelelwa ngezindlela ezahlukene, kodwa ngokuvamile sikhathazeka kakhulu ngebhalansi yethu yasebhange,” kusho uDkt. Xiao.
“Yebo, ihlaya leli, kodwa ngokomongo, konke okufunda ngamagundane ngeke kuhunyushwe kubantu. Uma ubuyigundane futhi ufuna ukuphila iminyaka engu-200 ubudala - noma okufana negundane. Eminyakeni engu-200 ubudala, lokho kungaba kuhle, kodwa ingabe kunengqondo kubantu? Lokho kuhlale kuyisixwayiso uma ngikhuluma ngocwaningo lwezilwane.”
"Ngasohlangothini oluhle, lolu ucwaningo oluqinile olusinika ubufakazi obuqinile bokuthi ngisho nezindlela eziningi ucwaningo lwami olugxile kuzo zibalulekile uma sicabanga ngokuphila ngokujwayelekile."
"Kungakhathaliseki ukuthi imodeli yezilwane noma imodeli yomuntu, kungase kube khona izindlela ezithile zamangqamuzana okudingeka sizibheke kumongo wokuhlolwa komtholampilo womuntu ngezinhlanganisela ezifana ne-grape seed proanthocyanidins," kusho uDkt. Siow.
UDkt. Xiao uthe enye into engenzeka wukwenza isivuno sembewu yamagilebhisi njengesithasiselo sokudla.
“Ukuba nesibonelo esihle sezilwane esinemiphumela emihle [kanye nokushicilelwa kujenali enethonya elikhulu] ngempela kunezela isisindo ekuthuthukisweni nasekutshalweni kwezimali ocwaningweni lwezokwelapha lwabantu, kungakhathaliseki ukuthi luvela kuhulumeni, ukuhlolwa kwemitholampilo noma ngabatshalizimali nezimboni. Thatha leli bhodi lenselelo bese ufaka imbewu yamagilebhisi kumaphilisi njengesengezo sokudla esisekelwe kulezi zihloko.”
“Isithasiselo engisisebenzisayo kungenzeka ukuthi asihlolwanga ngokomtholampilo, kodwa imininingwane yezilwane iveza ukuthi iyasinyusa isisindo – okwenza abathengi bakholwe ukuthi kukhona okukuso. Kuyingxenye yendlela abantu abacabanga ngayo ngokudla.” izithasiselo.” ngezindlela ezithile, lokhu kuyasiza ekuqondeni ukuphila isikhathi eside,” kusho uDkt Xiao.
UDkt. Xiao ugcizelele ukuthi izinga lempilo yomuntu nalo libalulekile, hhayi nje ukuthi uphila isikhathi esingakanani.
“Uma sinendaba neminyaka yokuphila, futhi okubaluleke nakakhulu, ubude besikhathi sokuphila, sidinga ukuchaza ukuthi iminyaka yokuphila isho ukuthini. Kulungile uma siphila size sibe ngu-150, kodwa akukuhle kangako uma sichitha iminyaka engu-50 silele.”
Ngakho esikhundleni sokuphila isikhathi eside, mhlawumbe igama elingcono kungaba impilo nokuphila isikhathi eside: ungase unezela iminyaka ekuphileni kwakho, kodwa ingabe uyenezela iminyaka ekuphileni kwakho? Noma ingabe le minyaka ayisho lutho? nempilo yengqondo: ungaphila iminyaka eyi-130. endala, kodwa uma ungakwazi ukujabulela le minyaka, ingabe kuyafaneleka?”
“Kubalulekile ukuthi sibheke umbono obanzi wempilo yengqondo kanye nempilo enhle, ubuthakathaka, izinkinga zokuhamba, indlela esiguga ngayo emphakathini - ingabe ikhona imithi eyanele? Noma ingabe sidinga ukunakekelwa komphakathi okwengeziwe? Uma sinokusekelwa ukuze siphile ku-90 , 100 noma 110? Ngabe uhulumeni unayo inqubomgomo?"
“Uma le mishanguzo isisiza, futhi sesineminyaka engaphezu kwekhulu, yini esingayenza ukuze sithuthukise izinga lempilo yethu kunokuthi sidle izidakamizwa eziningi? Lapha unembewu yamagilebhisi, amahalananda, njll.,” kusho uDkt. Xiao. .
USolwazi Bellantuono uthe imiphumela yocwaningo izobaluleka ikakhulukazi ezivivinyweni zomtholampilo ezibandakanya iziguli ezinomdlavuza ezithola i-chemotherapy.
"Inselelo evamile ngama-senolytics ukunquma ukuthi ubani ozohlomula kuwo nokuthi angayikala kanjani inzuzo ezivivinyweni zomtholampilo."
“Ngaphezu kwalokho, ngenxa yokuthi izidakamizwa eziningi ziphumelela kakhulu ekuvimbeleni izifo esikhundleni sokuselapha uma sesitholakele, ukuhlolwa komtholampilo kungathatha iminyaka kuye ngezimo futhi kungabiza kakhulu.”
“Kodwa-ke, kulokhu, [abacwaningi] bahlonze iqembu leziguli elizohlomula kulo: iziguli ezinomdlavuza ezithola ukwelashwa ngamakhemikhali. Ngaphezu kwalokho, kuyaziwa lapho ukwakheka kwamangqamuzana ezinzwa kubangelwa (okungukuthi nge-chemotherapy) nalapho “Lesi isibonelo esihle socwaningo lobufakazi obungenziwa ukuze kuhlolwe ukusebenza kwe-senolytics ezigulini,” kusho uSolwazi. Bellantuono. ”
Ososayensi bahlehlise ngempumelelo nangokuphephile izimpawu zokuguga kumagundane ngokuhlela kabusha ngokofuzo amanye amaseli awo.
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Ososayensi bafaka igazi lamagundane amadala kumagundane amancane ukuze babone umphumela futhi babone ukuthi bayayinciphisa yini futhi kanjani imiphumela yawo.
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