Esifundweni esisha, abacwaningi bathole ukuthi umuthi omusha osekelwe engxenyeni yembewu yamagilebhisi ungandisa ngempumelelo isikhathi sokuphila kanye nempilo yamagundane.
Lolu cwaningo, olushicilelwe ephephabhukwini i-Nature Metabolism, lubeka isisekelo sezifundo ezengeziwe zezokwelapha ukuze kutholakale ukuthi le miphumela ingaphindwa yini kubantu.
Ukuguga kuyisici esiyinhloko esiyingozi yezifo eziningi ezingamahlalakhona. Ososayensi bakholelwa ukuthi lokhu kungenxa yokuguga kwamangqamuzana. Lokhu kwenzeka lapho amangqamuzana engasakwazi ukwenza imisebenzi yawo yebhayoloji emzimbeni.
Eminyakeni yamuva nje, abacwaningi bathole uhlobo lwemithi ebizwa ngokuthi i-senolytics. Le mithi ingabhubhisa amangqamuzana asebekhulile elabhorethri nasezilwaneni, okungenzeka inciphise ukwanda kwezifo ezingamahlalakhona ezivelayo njengoba siguga futhi siphila isikhathi eside.
Kulolu cwaningo, ososayensi bathole i-senolytic entsha ethathwe engxenyeni yembewu yamagilebhisi ebizwa ngokuthi i-proanthocyanidin C1 (PCC1).
Ngokusekelwe kudatha yangaphambilini, i-PCC1 kulindeleke ukuthi ivimbele isenzo samaseli asebekhulile ngamanani aphansi futhi ibhubhise ngokukhetha amaseli asebekhulile ngamanani aphezulu.
Ekuhlolweni kokuqala, baveza amagundane emisebeni engababulali ukuze abangele ukuguga kwamangqamuzana. Iqembu elilodwa lamagundane labe selithola i-PCC1, kanti elinye iqembu lathola imoto ephethe i-PCC1.
Abacwaningi bathole ukuthi ngemva kokuba amagundane evezwe emisebeni, aqala ukuba nezici zomzimba ezingavamile, okuhlanganisa nezinwele eziningi ezimpunga.
Ukwelashwa kwamagundane nge-PCC1 kwashintsha kakhulu lezi zici. Amagundane anikezwe i-PCC1 nawo ayenamaseli amancane avuthiwe kanye nama-biomarker ahlobene namaseli avuthiwe.
Ekugcineni, amagundane ashiswe ngemisebe ayenamandla amancane okusebenza kanye nemisipha. Kodwa-ke, isimo sashintsha kumagundane ngenxa ye-PCC1, futhi ayenezinga eliphezulu lokusinda.
Ekuhlolweni kwesibili, abacwaningi bajova amagundane asebekhulile nge-PCC1 noma imoto njalo emavikini amabili izinyanga ezine.
Ithimba lithole inani elikhulu lamaseli asebekhulile ezinso, esibindini, emaphashini kanye nasezinhlayiyeni zamagundane amadala. Kodwa-ke, ukwelashwa nge-PCC1 kwashintsha isimo.
Amagundane aphathwe nge-PCC1 nawo abonise ukuthuthuka emandleni okubamba, isivinini esikhulu sokuhamba, ukukhuthazela kokulenga, ukukhuthazela kokuthambisa ibhayisikili, izinga lomsebenzi wansuku zonke, kanye nokulinganisela uma kuqhathaniswa namagundane athola imoto yodwa.
Kokuhlolwa kwesithathu, abacwaningi babheke amagundane amadala kakhulu ukuze babone ukuthi i-PCC1 ithinte kanjani impilo yawo.
Bathole ukuthi amagundane aphathwe nge-PCC1 aphila isikhathi eside ngo-9.4% kunamagundane aphathwe ngemoto.
Ngaphezu kwalokho, naphezu kokuphila isikhathi eside, amagundane aphathwe nge-PCC1 awazange abonise ukugula okuphezulu okuhlobene nobudala uma kuqhathaniswa namagundane aphathwe ngemoto.
Efingqa okutholakele, umbhali ohambisanayo uSolwazi Sun Yu waseShanghai Institute of Nutrition and Health eShayina kanye nozakwabo bathi: “Ngalokhu sinikeza ubufakazi besimiso sokuthi i-[PCC1] inamandla okulibazisa kakhulu ukungasebenzi kahle okuhlobene nokuguga ngisho noma ithathwa kamuva empilweni.”, inamandla amakhulu okunciphisa izifo ezihlobene nokuguga nokuthuthukisa imiphumela yezempilo, ngaleyo ndlela ivule izindlela ezintsha zokwelapha abantu asebekhulile esikhathini esizayo ukuze kuthuthukiswe impilo nokuphila isikhathi eside.”
UDkt. James Brown, ilungu le-Aston Center for Healthy Aging eBirmingham, e-UK, utshele i-Medical News Today ukuthi okutholakele kunikeza ubufakazi obengeziwe bezinzuzo ezingaba khona zemithi yokulwa nokuguga. UDkt. Brown wayengahilelekile ocwaningweni lwakamuva.
"Ama-senolytics ayisigaba esisha sama-compounds alwa nokuguga avame ukutholakala emvelweni. Lolu cwaningo lubonisa ukuthi i-PCC1, kanye nama-compounds afana ne-quercetin ne-fisetin, iyakwazi ukubulala amaseli asanda kuzalwa ngokukhetha ngenkathi ivumela amaseli amancane, anempilo ukuthi alondoloze impilo enhle."
"Lolu cwaningo, njengezinye izifundo kule ndawo, luhlole imiphumela yalezi zinhlanganisela kumagundane nakwezinye izinto eziphilayo eziphansi, ngakho-ke kusele umsebenzi omningi ngaphambi kokuba imiphumela yokulwa nokuguga yalezi zinhlanganisela kubantu itholakale."
“I-Senolytics ngokuqinisekile inesithembiso sokuba yimithi elwa nokuguga ehamba phambili ekuthuthukisweni,” kusho uDkt. Brown.
USolwazi u-Ilaria Bellantuono, uprofesa wokuguga kwemisipha eNyuvesi yaseSheffield e-UK, uvumile engxoxweni ne-MNT ukuthi umbuzo obalulekile ukuthi ngabe lokhu okutholakele kungaphindaphindwa yini kubantu. USolwazi uBellantuono naye wayengahilelekile kulolu cwaningo.
"Lolu cwaningo lunezela ebufakazini bokuthi ukuqondisa amangqamuzana asebekhulile ngemithi ewabulala ngokukhetha, ebizwa ngokuthi 'ama-senolytics,' kungathuthukisa ukusebenza komzimba njengoba sikhula futhi kwenze imithi ye-chemotherapy isebenze kangcono kumdlavuza."
“Kubalulekile ukuqaphela ukuthi yonke idatha kule ndawo ivela kumamodeli ezilwane—kulokhu, amamodeli egundane. Inselele yangempela ukuhlola ukuthi le mithi isebenza kahle yini [kubantu]. Akukho datha etholakalayo okwamanje.” , futhi izivivinyo zemitholampilo zisanda kuqala,” kusho uSolwazi uBellantuono.
UDkt. David Clancy, ovela kwi-Faculty of Biomedicine and Biological Sciences eLancaster University e-UK, utshele i-MNT ukuthi amazinga omthamo angaba yinkinga uma kusetshenziswa imiphumela kubantu. UDkt. Clancy akazange ahileleke ocwaningweni lwamuva nje.
"Imithamo enikezwa amagundane ivame ukuba mikhulu kakhulu uma iqhathaniswa nalokho abantu abangakubekezelela. Imithamo efanele ye-PCC1 kubantu ingabangela ubuthi. Izifundo kumagundane zingaba nolwazi; isibindi sawo sibonakala senza izidakamizwa zigaywe njengesibindi somuntu kunesibindi segundane."
UDkt. Richard Siow, umqondisi wocwaningo lokuguga eKing's College London, utshele ne-MNT ukuthi ucwaningo lwezilwane olungebona abantu lungase lungaholeli emiphumeleni emihle yezokwelapha kubantu. UDkt. Siow naye wayengahilelekile kulolu cwaningo.
“Angihlali ngifanisa ukutholakala kwamagundane, izimpethu nezimpukane nabantu, ngoba iqiniso elilula ukuthi sinama-akhawunti asebhange kanti wona awanawo. Sinezikhwama zemali, kodwa azinawo. Sinezinye izinto empilweni. Gcizelela ukuthi izilwane Asinazo: ukudla, ukuxhumana, umsebenzi, izingcingo ze-Zoom. Ngiyaqiniseka ukuthi amagundane angacindezeleka ngezindlela ezahlukene, kodwa ngokuvamile sikhathazeka kakhulu ngebhalansi yethu yasebhange,” kusho uDkt. Xiao.
"Yebo, lokhu kuyihlaya, kodwa ngokomongo, konke okufundayo ngamagundane akukwazi ukuhunyushwa kubantu. Ukube ubuyigundane futhi ufuna ukuphila iminyaka engu-200 ubudala - noma okufana negundane. Uma uneminyaka engu-200 ubudala, lokho kungaba kuhle, kodwa ingabe kunengqondo kubantu? Lokho kuhlale kuyisilumkiso uma ngikhuluma ngocwaningo lwezilwane."
"Ngakolunye uhlangothi oluhle, lolu ucwaningo oluqinile olusinika ubufakazi obuqinile bokuthi ngisho nezindlela eziningi ucwaningo lwami olugxile kuzo zibalulekile uma sicabanga ngokuphila impilo yonke."
“Kungakhathaliseki ukuthi kuyimodeli yesilwane noma imodeli yomuntu, kungase kube nezindlela ezithile zama-molecule okudingeka sizibheke kumongo wezivivinyo zemitholampilo zabantu ngama-compounds afana nama-proanthocyanidins embewu yamagilebhisi,” kusho uDkt. Siow.
UDkt. Xiao uthe enye indlela engenzeka ukuthuthukisa imbewu yamagilebhisi njengesengezo sokudla.
"Ukuba nemodeli yezilwane enhle enemiphumela emihle [kanye nokushicilelwa ephephabhukwini elinomthelela omkhulu] kunezela isisindo ekuthuthukisweni nasekutshalweni kwezimali ocwaningweni lwezokwelapha lwabantu, kungakhathaliseki ukuthi kuvela kuhulumeni, ezivivinyweni zezokwelapha noma ngabatshalizimali kanye nemboni. Thatha leli bhodi lezinselelo bese ubeka imbewu yamagilebhisi emathebulethini njengesengezo sokudla esisekelwe kulezi zihloko."
“Isengezo engisithathayo kungenzeka ukuthi asizange sihlolwe ngokwezokwelapha, kodwa idatha yezilwane iphakamisa ukuthi sandisa isisindo - okuholela abathengi ukuthi bakholelwe ukuthi kukhona okuthile kuso. Kuyingxenye yendlela abantu abacabanga ngayo ngokudla.” izithasiselo.” ngezindlela ezithile, lokhu kuyasiza ekuqondeni isikhathi eside,” kusho uDkt. Xiao.
UDkt. Xiao ugcizelele ukuthi ikhwalithi yokuphila komuntu nayo ibalulekile, hhayi nje ukuthi uphila isikhathi esingakanani.
"Uma sikhathalela isikhathi sokuphila, futhi okubaluleke kakhulu, isikhathi sokuphila, sidinga ukuchaza ukuthi kusho ukuthini isikhathi sokuphila. Kulungile uma siphila size sibe neminyaka engu-150, kodwa akukuhle kangako uma sichitha iminyaka engu-50 edlule embhedeni."
"Ngakho esikhundleni sokuphila isikhathi eside, mhlawumbe igama elingcono kungaba impilo nokuphila isikhathi eside: ungase wengeze iminyaka empilweni yakho, kodwa ingabe wengeza iminyaka empilweni yakho? Noma ingabe le minyaka ayinamsebenzi? Nempilo yengqondo: ungaphila uze ube neminyaka engu-130 ubudala, kodwa uma ungakwazi ukujabulela le minyaka, ingabe kuyakufanelekela lokho?"
"Kubalulekile ukuthi sibheke umbono obanzi wempilo yengqondo kanye nenhlalakahle, ubuthakathaka, izinkinga zokuhamba, indlela esiguga ngayo emphakathini - ingabe kukhona imithi eyanele? Noma ingabe sidinga ukunakekelwa okwengeziwe komphakathi? Uma sinokusekelwa ukuze siphile iminyaka engu-90, 100 noma 110? Ingabe uhulumeni unenqubomgomo?"
“Uma le mithi isisiza, futhi sineminyaka engaphezu kweyikhulu ubudala, yini esingayenza ukuze sithuthukise ikhwalithi yokuphila kwethu kunokuthatha nje imithi eyengeziwe? Lapha unembewu yamagilebhisi, amapomegranati, njll.,” kusho uDkt. Xiao.
USolwazi uBellantuono uthe imiphumela yocwaningo izoba usizo kakhulu ezivivinyweni zemitholampilo ezihilela iziguli ezinomdlavuza ezithola ukwelashwa ngamakhemikhali.
"Inselele evamile nge-senolytics ukunquma ukuthi obani abazozuza kuyo nokuthi ungayilinganisa kanjani inzuzo ezivivinyweni zemitholampilo."
"Ngaphezu kwalokho, ngenxa yokuthi imithi eminingi isebenza kahle kakhulu ekuvimbeleni izifo kunokwelapha uma sezitholakale, izivivinyo zemitholampilo zingathatha iminyaka kuye ngezimo futhi zingabiza kakhulu."
"Kodwa-ke, kulesi simo esithile, [abacwaningi] bathole iqembu leziguli ezazizozuza kukho: iziguli ezinomdlavuza ezithola ukwelashwa ngamakhemikhali. Ngaphezu kwalokho, kuyaziwa ukuthi ukwakheka kwamaseli avuthiwe kubangelwa nini (okungukuthi nge-chemotherapy) nokuthi "Lesi yisibonelo esihle socwaningo lobufakazi bomqondo olungenziwa ukuhlola ukusebenza kahle kwe-senolytics ezigulini," kusho uSolwazi uBellantuono.
Ososayensi baye baphumelela futhi balungisa ngokuphephile izimpawu zokuguga emagundwini ngokuhlela kabusha izakhi zofuzo zamanye amangqamuzana awo.
Ucwaningo lweBaylor College of Medicine luthole ukuthi izithasiselo zibambezela noma zilungisa izici zokuguga kwemvelo kumagundane, okungenzeka ukuthi zandise isikhathi…
Ucwaningo olusha kumagundane namangqamuzana abantu luthola ukuthi izakhi zezithelo zingase zehlise umfutho wegazi. Ucwaningo luphinde lwembule indlela yokufeza lo mgomo.
Ososayensi bafaka igazi lamagundane amadala emagundwini amancane ukuze babone umphumela futhi babone ukuthi banciphisa yini imiphumela yawo nokuthi bangayinciphisa kanjani.
Ukudla okulwa nokuguga kuya ngokuya kuthandwa. Kulesi sihloko sixoxa ngemiphumela yokubuyekezwa kwamuva kobufakazi futhi sibuze ukuthi ngabe kukhona yini…