Ukwethulwa kweCitrus Aurantium

I-Citrus Aurantium, isitshalo somndeni we-rutaceae, sisatshalaliswa kabanzi eShayina.I-Citrus aurantium igama lendabuko lesiShayina lomcako.Emithini yendabuko yamaShayina, i-citrus aurantium iyikhambi lesintu lendabuko elisetshenziselwa kakhulu ukwandisa isifiso sokudla kanye nokulawula i-qi (amandla).E-Italy, i-citrus aurantium nayo ibe yikhambi lesintu kusukela ngekhulu le-16, isetshenziselwa ukwelapha imfiva efana nomalaleveva kanye ne-ejenti elwa namagciwane.Ucwaningo lwakamuva lubonise ukuthi i-citrus aurantium ingangena esikhundleni se-ephedra ekwelapheni ukukhuluphala ngaphandle kwemiphumela emibi yenhliziyo nemithambo yegazi.

Ingxenye esebenzayo ye-citrus aurantium yi-hesperidin, neohesperidin, nobiletin, auranetin, aurantiamarin, nuringin, synephrine, limonin.

Isithako esisebenzayo

i-hesperidin, neohesperidin, nobiletin, D-limonene, auranetin, aurantiamarin, citrin, synephrine, limonin

Impahla ebonakalayo

I-Crystallization, iphoyinti elincibilikayo 184-1850C, i-carbonate crystallization 151-152, inyibilika kalula emanzini.I-Bitartrate, iphoyinti elincibilikayo 188-189, inyibilika emanzini, okunzima ukuyincibilika ku-ethanol, cishe ayincibiliki ku-chloroform, ether.I-Hydrochloride, i-crystal engenambala (i-ethanol-ethyl ether), iphuzu elincibilikayo 166-167.I-racemization kulula ukwenzeka ekuhlukaniseni i-chromatography ye-asidi eqinile nama-base ion exchange resins.

Umphumela we-Pharmacological
1. Umthelela esibelethweni: I-Fructus Aurantii kanye ne-Fructus Aurantii Fructus Decoction evela ezindaweni ezintathu ezihlukene ezikhiqizayo (i-Sichuan, i-Jiangxi, ne-Hunan) ibonise umthelela ovimbelayo esibelethweni se-vitro yamagundane (abakhulelwe nabangakhulelwe);Isibeletho sikanogwaja sasijabule kokubili ku-vivo kanye ne-in vitro (ekhulelwe futhi engakhulelwe).I-fistula yesibeletho sikanogwaja nayo yabonakala yenza ukufinyela kwesibeletho kuqine, ukushuba okukhulu, ngisho nokufinyela kwe-tetanic.I-tincture ye-Fructus Aurantii kanye ne-Fructus Aurantii fluid ekhishwayo ingase ijabulise isibeletho sikanogwaja (in vivo kanye ne-in vitro).Isibeletho segundane (in vitro) besivinjelwe.Into ye-alkaloid ehlukanisiwe ku-Fructus Aurantii ne-Lycium orange iphinde ibe nomthelela othile wokufinyela esibelethweni sikanogwaja ku-vitro, ikakhulukazi emsipha wesibeletho ojatshuliswe i-pituitrin.Ingxenye ye-alkaloid ekhishiwe yaba nomthelela wokuphumuza isibeletho sikanogwaja ku-vitro, futhi umphumela wokuphumuza kwesibeletho wabonakala kakhudlwana ngemva kokucasuka kwe-hypophysial.I-Cirantin, ehlukanisiwe ne-Fructus Aurantii Fructus Peel, ivimbela umsebenzi we-hyaluronate ezungeze i-ovary, okungenzeka ihlotshaniswe nomphumela wayo wokuvimbela inzalo (ukuvimbela ukuvundiswa).

2. Umthelela emathunjini: I-Fructus Aurantii kanye ne-Fructus Aurantii abavela ezindaweni ezintathu ezihlukene bavimbela amathumbu kumagundane nonogwaja;Iningi lamashubhu amathumbu konogwaja ayevinjiwe, kodwa ambalwa ayengenalo ushintsho.I-Fructus Aurantii kanye nokukhishwa kwayo okuwuketshezi kuvimbele amashubhu amathumbu amagundane (in vitro) nonogwaja (in vitro).Ukugxila okuphezulu (1:1000) kuvimbele amathumbu amancane onogwaja abangabodwa kanye nezingulube ze-Guinea futhi kwavimbela imiphumela ye-acetylcholine ne-histamine.Ukugxilisa ingqondo okuphansi (1:10 000), ngemva kwesikhathi esifushane sokuvinjelwa, kungabonisa umphumela wenjabulo, ukuphakama kwe-amplitude, kanye nemvamisa esheshayo.Ezinjeni ezibulala izinzwa, ukuba khona kwamathumbu kwakuvinjelwe ngokusobala ngama-decoctions.Kodwa ezinjeni ezine-gastroenterostomy, inomphumela othile ovusa amadlingozi, ongenza ukunyakaza kwamathumbu kanye nesigqi sokufinyela sibe namandla.

3. Imithelela enhliziyweni nasemithanjeni yegazi: inani elincane lokujabula kanye nenani elikhulu lokuvinjelwa enhliziyweni yeselesele ku-vitro.I-Fructus Aurantii ne-Fructus Aurantii Aurantii i-aqueous decoction, i-Fructus Aurantii tincture, kanye ne-fluid extract kuyafana.I-decoction ye-Fructus Aurantii noma i-alcohol ekhishwe nge-intravenously ingaholela ekuthuthukisweni okubalulekile kokucindezela.I-Fructus Aurantii kanye ne-Fructus Aurantii Fructus ezivela ezindaweni zokuhlala ezintathu ezihlukene kwafakazelwa ukuthi banemiphumela ethambile ye-vasoconstriction ngokufakwa kwemithambo yomzimba wonke yamaxoxo.Ezinjeni ezilaliswa izinzwa, kwaba nomphumela ophawulekayo futhi osheshayo we-hypertensive.Kwakungekho ukucindezeleka kokuphefumula noma i-hypotension ebangelwa i-epinephrine, futhi kwakungekho ukwanda okusobala kwesilinganiso senhliziyo.

Indlela yokukhulisa ingcindezi ihlobene nalezi zinto ezilandelayo:

3.1.Ukuvuswa kwama-α receptors, okubangela i-vasoconstriction kwezinye izitho (i-phenylzoline ingahlehlisa ingcindezi ibe ukusabela kwe-antihypertensive).

3.2.Ukufinyela okuthuthukisiwe kwe-myocardial kanye nokwanda kokuphuma kwenhliziyo (i-guinea pig heart perfusion eyedwa kanye nokulungiswa kwe-cardiopulmonary).Ngemuva kwe-reserpine, umphumela wokukhulisa ingcindezi we-Fructus aurantii aurantii wawubaluleke kakhulu.Yandisa kakhulu ukugeleza komthambo we-coronary (289.4% yandisa ukugeleza komthambo we-coronary nge-bubble flowmeter) futhi yandisa ukugeleza kwegazi lobuchopho nezinso ngo-86.4% no-64.5% ngokwesilinganiso, okwakuhluke kakhulu ku-norepinephrine.Kube nokuncipha kokugeleza kwegazi wesifazane kanye nokwanda okuncane kodwa okungabalulekile ekusetshenzisweni kwe-oksijeni ye-myocardial, engazange ihambisane nokwanda okuphawulekayo kokugeleza kwe-coronary.Ekuhlolweni kwe-ECG ezinjeni nasezingulubeni, i-arrhythmia (i-ventricular tachycardia noma i-atrioventricular block) ebangelwa umthamo omkhulu we-aurantii aurantii yayingeyona into ebucayi.Ngokusekelwe ezicini ezingenhla, kuye kwaphakanyiswa ukwelapha ukushaqeka kwe-cardiogenic.Ama-alkaloid ahlukanisiwe ku-Fructus Aurantii kanye ne-Lycium orange angakwazi futhi ukuthuthukisa okwesikhashana ukungezwani kwemisipha ebushelelezi yemithambo, ikakhulukazi uma yelashwa nge-pituitrin.

4. I-Antithrombotic: Ukuhlolwa kwe-in vitro kwe-0.1g/ml i-Fructus Aurantii aqua decoction ibonise umphumela ocacile we-antithrombotic.

5. I-Anti-allergic reaction: 100mg/kg static pulse injection of Fructus Aurantii Aurantii water extract can inhibit passive skin allergic reaction (PCA) kumagundane, kanye ne-50μg/ml ingavimbela ukukhululwa kwe-histamine kuma-rat mast cells.

6. Eminye imiphumela: I-Citrus plant mycin inganciphisa okuqukethwe kwe-cholestatin ku-serum nesibindi samagundane adla ukudla okuqukethe i-cholesterol.I-alcohol ekhishwe ye-Fructus Aurantii ibe nomthelela ovimbelayo ku-mycobacterium tuberculosis H37Rv in vitro, futhi ukugxila kwayo kokuvimbela kwaba ngu-1:1000.I-decoction yayo enamanzi ayizange ibe nomthelela ku-guinea pig bronchus.Kuye kwabikwa ukuthi ijusi yezithelo ezisawolintshi inyusa izinga lokuvutshelwa kwemvubelo futhi ayinciphisi umsebenzi wayo ngemva kokubilisa, ngakho ayiyona ingxenye ye-enzymatic.Ukusetshenziswa okuyinhloko kwejusi yamawolintshi kwezokwelapha ukuthi inovithamini C futhi iqukethe inani elikhulu lamavithamini A no-B. Ikhasi alinawo uvithamini C kodwa linovithamini A ocebile. Libaba futhi lingaqinisa isisu.Izingane ezinjengokuthatha inqwaba yamapeel zingabangela ubuthi (ubuhlungu besisu, amajaqamba).

Inkomba:http://www.a-hospital.com

NgobaI-Citrus Aurantium Extract, sicela usithinte.Sikulindile la noma nini!!!