Ukwethulwa kwe-Citrus Aurantium

I-Citrus Aurantium, isitshalo esingomndeni we-rutaceae, sisakazwa kabanzi eShayina. I-Citrus aurantium igama lesiShayina lendabuko le-lime. Emithini yesiShayina yendabuko, i-citrus aurantium iyisitshalo sendabuko esisetshenziswa kakhulu ukwandisa isifiso sokudla nokulawula i-qi (amandla). E-Italy, i-citrus aurantium ibilokhu iyikhambi lendabuko kusukela ngekhulu le-16, elisetshenziselwa ukwelapha umkhuhlane ofana nomalaleveva kanye ne-antimicrobial agent. Izifundo zakamuva zikhombisile ukuthi i-citrus aurantium ingathatha indawo ye-ephedra ekwelapheni ukukhuluphala ngaphandle kwemiphumela emibi yenhliziyo.

Isakhi esisebenzayo se-citrus aurantium yi-hesperidin, neohesperidin, nobiletin, auranetin, aurantiamarin, nuringin, synephrine, limonin.

Isithako esisebenzayo

i-hesperidin, i-neohesperidin, i-nobiletin, i-D-limonene, i-auranetin, i-aurantiamarin, i-citrin, i-synephrine, i-limonin

Impahla engokoqobo

Ukwakheka kwekristalu, iphuzu lokuncibilika 184-1850C, ukwakheka kwekristalu ye-carbonate 151-152, kuncibilika kalula emanzini. I-Bitartrate, iphuzu lokuncibilika 188-189, kuncibilika emanzini, kunzima ukuncibilika ku-ethanol, cishe akuncibiliki ku-chloroform, i-ether. I-Hydrochloride, ikristalu engenambala (i-ethanol-ethyl ether), iphuzu lokuncibilika 166-167. Ukwakheka kwe-racemization kulula ukwenzeka ekuhlukanisweni kwe-chromatography kwama-resin okushintshana kwe-acid enamandla kanye ne-base ion.

Umphumela wezokwelapha
1. Umphumela esibelethweni: I-Fructus Aurantii kanye ne-Fructus Aurantii I-Fructus Decoction evela ezindaweni ezintathu ezihlukene zokukhiqiza (i-Sichuan, i-Jiangxi, kanye ne-Hunan) ibonise umphumela wokuvimbela esibelethweni ngaphakathi kwe-vitro yamagundane (akhulelwe nangakakhulelwa); Isibeletho sikanogwaja sasivuselelwe kokubili ngaphakathi kwe-vivo kanye nase-vitro (sikhulelwe futhi asikhulelwe). I-fistula yesibeletho sikanogwaja nayo yabonakala yenza ukuvinjelwa kwesibeletho kube namandla, kwanda ukucindezeleka, ngisho nokuvinjelwa kwe-tetanic. I-tincture ye-Fructus Aurantii kanye ne-Fructus Aurantii fluid extract nayo ingavusa isibeletho sikanogwaja (ngaphakathi kwe-vivo kanye nase-vitro). Isibeletho segundane (ngaphakathi kwe-vitro) savinjelwa. Into ye-alkaloid ekhishwe ku-Fructus Aurantii kanye ne-Lycium orange nayo yayinomphumela othile wokuvinjelwa esibelethweni sikanogwaja ngaphakathi kwe-vitro, ikakhulukazi emisipheni yesibeletho evuselelwe yi-pituitrin. Ingxenye ye-alkaloid esusiwe yayinomphumela wokuphumula esibelethweni sikanogwaja ngaphakathi kwe-vitro, futhi umphumela wokuphumula wesibeletho wawusobala kakhulu ngemva kokuphazamiseka kwe-hypophysial. I-Cirantin, ekhishwe ku-Fructus Aurantii Fructus Peel, ivimbela umsebenzi we-hyaluronate ozungeze isibeletho, okungase kuhlobane nomphumela wayo wokuvimbela ukukhulelwa (ukuvimbela ukukhulelwa).

2. Umphumela emathunjini: I-Fructus Aurantii kanye ne-Fructus Aurantii ezivela ezindaweni ezintathu ezahlukene zokuhlala zavimbela amathumbu kumagundane nakonogwaja; Iningi lamapayipi amathumbu konogwaja lavinjwa, kodwa ambalwa awazange ashintshe. I-Fructus Aurantii kanye noketshezi lwayo lwavimbela amapayipi amathumbu amagundane (in vitro) kanye nonogwaja (in vitro). Ukuhlushwa okuphezulu (1:1000) kwavimbela amathumbu amancane onogwaja abahlukanisiwe kanye nezingulube ze-Guinea futhi kwavimbela imiphumela ye-acetylcholine kanye ne-histamine. Ukuhlushwa okuphansi (1:10 000), ngemva kwesikhathi esifushane sokuvinjwa, kungabonisa umphumela wokuvusa, ukuphakama kwanda, kanye nokuvama kwanda. Ezinjeni ezidakiwe, ukuba khona kwamathumbu kwavinjwa ngokusobala ngama-decoction. Kodwa ezinjeni ezine-gastroenterostomy, inomphumela othile wokuvusa, ongenza ukunyakaza kwamathumbu kanye nesigqi sokuqunjelwa kube namandla.

3. Imiphumela enhliziyweni nasemithanjeni yegazi: inani elincane lokuvuvuka kanye nenani elikhulu lokuvinjelwa enhliziyweni yexoxo in vitro. I-Fructus Aurantii kanye ne-Fructus Aurantii Aurantii decoction yamanzi, i-Fructus Aurantii tincture, kanye ne-fluid extract kuyafana. I-Fructus Aurantii decoction noma i-alcohol extract efakwe ngemithambo yegazi ingabangela ukuthuthukiswa okukhulu kwengcindezi. I-Fructus Aurantii kanye ne-Fructus Aurantii I-Fructus evela ezindaweni ezintathu ezahlukene ifakazelwe ukuthi inemiphumela emincane ye-vasoconstriction ngokugeleza kwemithambo yegazi yamaxoxo emzimbeni wonke. Ezinjeni ezidakwe i-anesthesia, kube nomphumela ophawulekayo nosheshayo we-hypertension. Kwakungekho ukucindezeleka kokuphefumula noma i-hypotension okubangelwa yi-epinephrine, futhi kwakungekho ukwanda okusobala kwesilinganiso senhliziyo.

Indlela yokwandisa ingcindezi ihlobene nalezi zinto ezilandelayo:

3.1. Ukuvusa ama-receptor e-α, okubangela ukuminyana kwemithambo yegazi kwezinye izitho zomzimba (i-phenylzoline ingaguqula ukukhushulwa kwengcindezi kube ukusabela kokunciphisa umfutho wegazi).

3.2. Ukuqina kwenhliziyo okuthuthukisiwe kanye nokwanda kokukhipha kwenhliziyo (ukugeleza kwenhliziyo yengulube ye-guinea ehlukanisiwe kanye nokulungiselela i-cardiopulmonary). Ngemuva kwe-reserpine, umphumela wokukhulisa ingcindezi we-Fructus aurantii aurantii wawubaluleke kakhulu. Kwandise kakhulu ukugeleza kwemithambo yenhliziyo (289.4% kwandise ukugeleza kwemithambo yenhliziyo nge-bubble flowmeter) kanye nokwanda kokugeleza kwegazi lobuchopho nezinso ngo-86.4% kanye no-64.5% ngokwesilinganiso, okwakuhluke kakhulu ku-norepinephrine. Kwakukhona ukwehla kokugeleza kwegazi le-femoral kanye nokwanda okuncane kodwa okungabalulekile kokusetshenziswa komoya-mpilo we-myocardial, okwakungahambisani nokwanda okukhulu kokugeleza kwenhliziyo. Ekuhlolweni kwe-ECG ezinjeni nasezingulubeni ze-guinea, i-arrhythmia (i-ventricular tachycardia noma i-atrioventricular block) okubangelwa umthamo omkhulu we-aurantii aurantii kwakungekubi kangako. Ngokusekelwe ezicini ezingenhla, kuye kwaphakanyiswa ukuthi kwelashwe ukushaqeka kwenhliziyo. Ama-Alkaloid ahlukaniswe ne-Fructus Aurantii kanye ne-Lycium orange nawo angathuthukisa okwesikhashana ukucindezeleka kwemisipha ebushelelezi yemithambo yegazi, ikakhulukazi lapho ephathwa nge-pituitrin.

4. I-Antithrombotic: Ukuhlolwa kwe-in vitro kwe-0.1g/ml ye-Fructus Aurantii aqua decoction kubonise umphumela osobala we-antithrombotic.

5. Ukusabela okulwa nokungezwani komzimba: Umjovo we-100mg/kg we-static pulse we-Fructus Aurantii Aurantii water extract ungavimbela ukusabela kokungezwani komzimba kwesikhumba (PCA) kumagundane, kanti i-50μg/ml ingavimbela ukukhishwa kwe-histamine kumaseli e-mast esiswini samagundane.

6. Eminye imiphumela: I-mycin yesitshalo se-citrus inganciphisa okuqukethwe kwe-cholestatin egazini nasesibindini samagundane adla ukudla okuqukethe i-cholesterol. I-alcohol extract ye-Fructus Aurantii ibe nomphumela wokuvimbela isifo sofuba se-mycobacterium H37Rv in vitro, futhi ukuhlushwa kwayo kokuvimbela kwakuyi-1:1000. I-decoction yayo yamanzi ayizange ibe nomthelela ku-guinea pig bronchus. Kubikwe ukuthi ijusi yezithelo ze-citrus ikhulisa izinga lokubila kwemvubelo futhi ayinciphisi umsebenzi wayo ngemva kokubila, ngakho-ke akuyona ingxenye ye-enzyme. Ukusetshenziswa okuyinhloko kwezokwelapha kwejusi le-orange ukuthi licebile nge-vitamin C futhi liqukethe inani elikhulu lamavithamini A no-B. I-peel ayiqukethe i-vitamin C kodwa icebile nge-vitamin A. Inambitheka ebabayo futhi ingaqinisa isisu. Izingane ezifana nokuthatha inani elikhulu lama-peel zingabangela ubuthi (ubuhlungu besisu, ukuqaqamba).

Ireferensi: http://www.a-hospital.com

NgobaI-Citrus Aurantium Extract, sicela usithinte. Sikulindele lapha noma nini!!!