Umdlavuza wamaphaphu uwuhlobo lwesibili lomdlavuza oluvame kakhulu emhlabeni. Ngo-2020, abantu abangaphezu kwezigidi ezi-2.2 emhlabeni wonke bazotholakala benomdlavuza wamaphaphu okokuqala ngqa. Ngawo lowo nyaka, cishe abantu abayizigidi ezingu-1.8 emhlabeni wonke babulawa umdlavuza wamaphaphu.
Nakuba okwamanje lingekho ikhambi lomdlavuza wamaphaphu, ososayensi basebenzela izindlela zokwelapha. Abanye balaba sosayensi basebenza eNyuvesi Yezobuchwepheshe eSydney (UTS), lapho ucwaningo olusha lubonise ukuthi inhlanganisela yezitshalo zemvelo ebizwa ngokuthi i-berberine ingamisa ukukhula kwamangqamuzana omdlavuza wamaphaphu elabhorethri.
I-Berberine iyinhlanganisela yezitshalo eyenzeka ngokwemvelo ebisetshenziswa emithini yendabuko yamaShayina izinkulungwane zeminyaka. Itholakala ezitshalweni ezihlukahlukene, okuhlanganisa i-barberry, i-goldenseal, i-Oregon yamagilebhisi, kanye ne-turmeric yesihlahla.

(Umkhiqizo wethuI-Berberine Extract, wamukelekile ngokuzithoba ukubuza.)

Iminyaka yocwaningo ibonise ukuthi i-berberine iyasebenza ekusizeni abantu abanesifo sikashukela sohlobo 2 ukulawula amazinga kashukela egazini futhi ingasiza ekwelapheni i-metabolic syndrome.
Abacwaningi bathole nokuthi i-berberine ingasetshenziswa ukwelapha izinhlobo ezahlukene zomdlavuza, kuhlanganise nomdlavuza wesibeletho, wesisu nowebele.
NgokukaDkt. Kamal Dua, Umfundisi Omkhulu kanye Nomlingani Omkhulu Wokucwaninga ekhemisi e-Australian Research Center for Complementary and Integrative Medicine (ARCCIM), University of Technology Sydney (UTS) School of Medicine kanye nombhali oholayo wocwaningo, uBerberine uvimbela izihluthulelo ezimbili. izinqubo ekuthuthukisweni komdlavuza - Ukusabalala nokufuduka kwamaseli.
“Ngokwemishini, lokhu kungafinyelelwa ngokuvimbela izakhi zofuzo ezibalulekile njenge-P53, PTEN ne-KRT18 kanye namaprotheni afana ne-AXL, CA9, ENO2, HER1, HER2, HER3, PRGN, PDGF-AA, DKK1, CTSB, CTSD, BCLX, CSF1. kanye neCAPG ehambisana nokwanda nokufuduka kwamangqamuzana omdlavuza,” echaza.
Ocwaningweni lwamanje, ithimba labacwaningi elihlanganisa uDkt. Dua, uDkt. Keshav Raj Paudel, uProfesa Philip M. Hansbrough noDkt Bikash Manandhar we-UTS, kanye nabasebenzi baseMalaysian International Medical University kanye ne-Al Qasim University eSaudi Arabia, wafunda ukuthi i-berberine ingasetshenziswa kanjani ekwelapheni umdlavuza wamaphaphu.
"Ukusetshenziswa komtholampilo kwe-berberine kunqunyelwe ngenxa yokungancibiliki kahle kwayo kanye ne-bioavailability," kuchaza uDkt. Dua we-MNT. "Umgomo oyinhloko walolu cwaningo ukuthuthukisa imingcele ye-physicochemical ye-berberine ngokuguqula i-berberine ibe i-crystal nanoparticles ewuketshezi kanye nokuhlola amandla ayo okulwa nomdlavuza ku-in vitro kumaseli e-alveolar epithelial basal adenocarcinoma A549."
Ithimba labacwaningi lenze uhlelo oluthuthukisiwe lokulethwa kwezidakamizwa oluhlanganisa i-berberine ezindaweni ezincane ezincibilikayo nezibolayo. Lawa ma-nanoparticles e-crystal ewuketshezi asetshenziselwe ukwelapha amangqamuzana omdlavuza wamaphaphu womuntu ku-vitro elabhorethri.
Ekupheleni kocwaningo, ithimba lithole ukuthi i-berberine yasiza ukuvimbela ukukhiqizwa kwezinhlobo ze-oksijeni ezisebenzayo, amakhemikhali avuthayo akhiqizwa amangqamuzana athile ekuphenduleni ukuhlasela kwamagciwane nezinye izenzakalo ezicindezelayo ezingalimaza amangqamuzana.
Ngaphezu kwalokho, i-berberine isiza ukulawula izakhi zofuzo ezihambisana nokucindezeleka kwe-oxidative nokuvuvukala, futhi isiza ukunciphisa ukuguga kwamangqamuzana ngaphambi kwesikhathi.
"Siye sabonisa ukuthi, ngokusebenzisa indlela ye-nanotechnological, izakhiwo ze-compound zingathuthukiswa ukuze zibhekane nezinkinga ezihlukahlukene ezihlobene nokuncibilika, ukutholwa kwamaselula, kanye nempumelelo yokwelapha," kuchaza uDkt Dua. I-Anticancer Potential I-berberine liquid crystal nanoparticles yethu ibonise umsebenzi ofanayo izikhathi ezinhlanu kunomthamo uma kuqhathaniswa nezincwadi ezishicilelwe, okubonisa ngokucacile izinzuzo ze-nanodrugs. "
Ukuqhubeka nokuhlola le miphumela, uDkt. Dua uthe uhlela ukusebenzisa inkundla entsha yocwaningo ukwenza izifundo ezijulile esebenzisa izinhlobo zezilwane ezitholakala ngaphambi komtholampilo zomdlavuza wamaphaphu.
"Izifundo ezengeziwe ze-pharmacokinetic kanye ne-anticancer ye-berberine nanodrugs emifanekisweni yezilwane ku-vivo ingase iveze izinzuzo zabo ezingase zibe khona ekwelapheni umdlavuza wamaphaphu futhi ziguqule zibe amafomu omthamo wokwelapha," echaza.
"Uma sesiqinisekisile amandla okulwa nomdlavuza we-berberine nanodrugs emifanekisweni yezilwane zangaphambi komtholampilo, isinyathelo esilandelayo sizoba ukuthuthela ekuhlolweni kwemitholampilo, esesivele sixoxisana nezinkampani eziningi zaseSydney," kusho uDkt. Dua.
Ngaphezu kwalokho, uDkt. Dua wathi amandla e-berberine okuvimbela ukuphindelela komdlavuza wamaphaphu adinga ukuqinisekiswa: “Nakuba singakaphenyi ngalokhu, sihlela ukuyifunda ezifundweni ezizayo, futhi sikholelwa ukuthi i-berberine nanoforms izobonisa. umsebenzi othembisayo. “.
UDkt Osita Onuga, udokotela ohlinza isifuba kanye noprofesa osizayo wokuhlinzwa kwesifuba e-St. John Cancer Institute e-Providence St. John Medical Center eSanta Monica, eCalifornia, utshele i-MNT ukuthi lapho abacwaningi bethola amathuba amasha okwelapha nokuvimbela umdlavuza, kuhlale kukhona. ithemba:
“I-Berberine iyingxenye yemithi yaseMpumalanga, ngakho-ke asiyisebenzisi ngokwesiko kwezokwelapha zaseNtshonalanga. Ngicabanga ukuthi kuyathakazelisa ngoba sibheka lokho esikwaziyo ukuthi kunezinzuzo ezithile zezinto zemithi yaseMpumalanga, futhi sikufake ocwaningweni ukuze kusize ukuhumushela lokho kwezokwelapha zaseNtshonalanga. “.
"Kuhlale kuthembisa, kepha kuselebhu, futhi okuningi esikuthola elebhu akuholeli ekulashweni kweziguli," kuqhubeka u-Onuga. "Ngicabanga ukuthi into elandelayo okufanele yenziwe ukwenza izivivinyo ezithile zomtholampilo ezigulini futhi sithole umthamo."
Abanye abantu baba nezimpawu ezicashile zomdlavuza wamaphaphu ezigabeni zokuqala zesifo. Qhubeka ufunde ukuze ufunde kabanzi, okuhlanganisa ukuthi uyobonana nini nodokotela.
Umdlavuza wamaphaphu kwenzeka ngamanani ahlukene kwabesifazane nabesilisa, kodwa izimpawu nezici zobungozi ziyefana. Lapha sichaza izakhi zofuzo kanye namahomoni okungenzeka…
Singumkhiqizi ochwepheshe okhipha impushana yezitshalo, siyakwamukela ukukuthumelela noma yimiphi imibuzo mayelana nomkhiqizo wethu futhi sinozakwethu onomthwalo wemfanelo wokuxazulula izinkinga zakho mayelana nokudayiswa kwangaphambili nangemuva kokuthengisa. Xhumana nathi nganoma yisiphi isikhathi !!!