Umdlavuza wamaphaphu uhlobo lwesibili oluvame kakhulu lomdlavuza emhlabeni. Ngo-2020, abantu abangaphezu kwezigidi ezingu-2.2 emhlabeni wonke bazotholakala benomdlavuza wamaphaphu okokuqala. Ngonyaka ofanayo, cishe abantu abayizigidi ezingu-1.8 emhlabeni wonke babulawa umdlavuza wamaphaphu.
Nakuba okwamanje kungekho ukwelashwa komdlavuza wamaphaphu, ososayensi basebenza ngezindlela zokwelapha. Abanye balaba ososayensi basebenza e-University of Technology eSydney (UTS), lapho ucwaningo olusha lubonise khona ukuthi isitshalo semvelo esibizwa ngokuthi i-berberine singavimba ukukhula kwamaseli omdlavuza wamaphaphu elabhorethri.
I-Berberine iyisitshalo esitholakala ngokwemvelo esisetshenziswe emithini yendabuko yaseShayina izinkulungwane zeminyaka. Itholakala ezitshalweni ezahlukahlukene, kufaka phakathi i-barberry, i-goldenseal, i-Oregon grape, kanye ne-tree turmeric.

(Umkhiqizo wethuI-Berberine Extract, wamukelekile ngobuqotho ekubuzeni.)

Iminyaka eminingi yocwaningo ikhombisile ukuthi i-berberine iyasebenza ekusizeni abantu abanesifo sikashukela sohlobo lwesibili ukulawula amazinga abo kashukela egazini futhi ingasiza ekwelapheni i-metabolic syndrome.
Abacwaningi bathole nokuthi i-berberine ingasetshenziswa ukwelapha izinhlobo ezahlukene zomdlavuza, okuhlanganisa umdlavuza wesibeletho, isisu kanye nesifuba.
Ngokusho kukaDkt. Kamal Dua, uMqeqeshi Omkhulu kanye noMcwaningi Omkhulu kwiKhemisi e-Australian Research Center for Complementary and Integrative Medicine (ARCCIM), e-University of Technology Sydney (UTS) School of Medicine kanye nombhali oholayo walolu cwaningo, i-Berberine ivimbela izinqubo ezimbili ezibalulekile ekuthuthukisweni komdlavuza - ukwanda kanye nokufuduka kwamaseli.
“Ngokomshini, lokhu kungafezwa ngokuvimbela izakhi zofuzo ezibalulekile njenge-P53, i-PTEN kanye ne-KRT18 kanye namaprotheni afana ne-AXL, i-CA9, i-ENO2, i-HER1, i-HER2, i-HER3, i-PRGN, i-PDGF-AA, i-DKK1, i-CTSB, i-CTSD, i-BCLX, i-CSF1. kanye ne-CAPG ehlotshaniswa nokwanda nokufuduka kwamaseli omdlavuza,” echaza.
Ocwaningweni lwamanje, ithimba locwaningo elihlanganisa uDkt. Dua, uDkt. Keshav Raj Paudel, uSolwazi Philip M. Hansbrough noDkt. Bikash Manandhar be-UTS, kanye nabasebenzi baseMalaysian International Medical University kanye ne-Al Qasim University eSaudi Arabia, bafunde ukuthi i-berberine ingasetshenziswa kanjani ekwelapheni umdlavuza wamaphaphu.
“Ukusetshenziswa kwe-berberine emtholampilo kunqunyelwe ngenxa yokuncibilika kwayo okuncane kanye nokutholakala kwayo emzimbeni,” kuchaza uDkt. Dua we-MNT. “Umgomo oyinhloko walolu cwaningo ukuthuthukisa imingcele ye-physicochemical ye-berberine ngokuguqula i-berberine ibe yi-nanoparticles ye-liquid crystal kanye nokuhlola amandla ayo okulwa nomdlavuza in vitro kumaseli e-alveolar epithelial basal epithelial e-human adenocarcinoma A549.”
Ithimba locwaningo lisungule uhlelo lokulethwa kwemithi oluthuthukisiwe oluhlanganisa i-berberine ezindaweni ezincane ezincibilikayo nezibolayo. Lezi zinhlayiya ezincane zekristalu eliwuketshezi zisetshenziswe ukwelapha amangqamuzana omdlavuza wamaphaphu womuntu ngaphakathi kwe-vitro elabhorethri.
Ekupheleni kocwaningo, ithimba lithole ukuthi i-berberine isize ekuvimbeleni ukukhiqizwa kwezinhlobo ze-oxygen ezisebenzayo, amakhemikhali okuvuvukala akhiqizwa amaseli athile ekuphenduleni ukuhlasela kwamagciwane kanye nezinye izehlakalo ezicindezelayo ezingalimaza amaseli.
Ngaphezu kwalokho, i-berberine isiza ukulawula izakhi zofuzo ezihambisana nokucindezeleka kwe-oxidative kanye nokuvuvukala, futhi isiza ekunciphiseni ukuguga kwamangqamuzana ngaphambi kwesikhathi.
“Siye sabonisa ukuthi, sisebenzisa indlela ye-nanotechnological, izakhiwo ze-compound zingathuthukiswa ukuze kuxazululwe izinkinga ezahlukahlukene ezihlobene nokuncibilika, ukumuncwa kwamaseli, kanye nokusebenza kahle kokwelapha,” kuchaza uDkt. Dua. Amandla Okulwa Nomdlavuza Ama-nanoparticles ethu e-berberine liquid crystal abonise umsebenzi ofanayo ngesilinganiso esiphindwe kahlanu uma kuqhathaniswa nezincwadi ezishicilelwe, okubonisa ngokusobala izinzuzo ze-nanodrugs.”
Ukuze aqhubeke nokuhlola le miphumela, uDkt. Dua uthe uhlela ukusebenzisa ipulatifomu entsha yocwaningo ukwenza izifundo ezijulile esebenzisa izinhlobo zezilwane zomdlavuza wamaphaphu ngaphambi kokwelashwa.
“Ucwaningo olwengeziwe lwe-pharmacokinetic kanye nolwe-anticancer lwe-berberine nanodrugs kumamodeli ezilwane angaphakathi emzimbeni lungase lwembule izinzuzo ezingaba khona ekwelapheni umdlavuza wamaphaphu futhi luwaguqule abe amafomu omthamo wokwelapha,” echaza.
“Uma sesiqinisekisile amandla okulwa nomdlavuza we-berberine nanodrugs kumamodeli ezilwane angaphambi kokwelashwa, isinyathelo esilandelayo kuzoba ukudlulela ezivivinyweni zezokwelapha, esisezingxoxweni kakade nezinkampani eziningana zaseSydney,” kusho uDkt. Dua.
Ngaphezu kwalokho, uDkt. Dua uthe amandla e-berberine okuvimbela ukuphindaphinda komdlavuza wamaphaphu kudingeka aqinisekiswe: “Nakuba singakaphenyi ngalokhu, sihlela ukukutadisha ezifundweni zesikhathi esizayo, futhi sikholelwa nokuthi ama-nanoform e-berberine azobonisa umsebenzi othembisayo.”
UDkt. Osita Onuga, udokotela ohlinzayo wesifuba kanye noprofesa osizayo wokuhlinzwa kwesifuba eSt. John Cancer Institute eProvidence St. John Medical Center eSanta Monica, eCalifornia, utshele i-MNT ukuthi lapho abacwaningi bethola amathuba amasha okwelapha nokuvimbela umdlavuza, kuhlale kukhona ithemba:
"I-Berberine iyingxenye yezokwelapha zaseMpumalanga, ngakho-ke asiyisebenzisi ngokwesiko kwezokwelapha zaseNtshonalanga. Ngicabanga ukuthi kuyathakazelisa ngoba sibheka lokho esikwaziyo ukuthi kunezinzuzo ezithile kwezokwelapha zaseMpumalanga, futhi sikufake ocwaningweni ukuze kusize ekuhumusheni lokho kwezokwelapha zaseNtshonalanga."
“Kuhlala kuthembisa, kodwa kuse-lab, futhi okuningi esikutholayo e-lab akusho ukuthi iziguli zelashwe,” kuqhubeka u-Onuga. “Ngicabanga ukuthi into elandelayo okufanele yenziwe ukwenza ezinye izivivinyo zemitholampilo ezigulini bese uthola umthamo.”
Abanye abantu babhekana nezimpawu ezingabonakali zomdlavuza wamaphaphu ezigabeni zokuqala zalesi sifo. Qhubeka ufunda ukuze ufunde kabanzi, okuhlanganisa nokuthi kufanele ubonane nini nodokotela.
Umdlavuza wamaphaphu uvela ngamazinga ahlukene kwabesifazane nabesilisa, kodwa izimpawu kanye nezici eziyingozi ziyafana. Lapha sichaza ufuzo kanye nama-hormone okungenzeka…
Singumkhiqizi wempuphu yezitshalo ochwepheshe, siyakwamukela ukukuthumelela noma yimiphi imibuzo mayelana nomkhiqizo wethu futhi sinozakwethu othembekile ukuxazulula izinkinga zakho mayelana nokuthengiswa kwangaphambilini kanye nokuthengiswa ngemuva kokuthengiswa. Xhumana Nathi Noma Kunini!!!