1. Abamelene ne-Endothelin

Ikhishwe ku-chamomile yemifino yaseYurophu, engamelana ne-endothelin futhi ivimbele ukukhiqizwa kwama-melanocyte. Ukusabalalisa okungalingani kwe-endothelin esikhumbeni kuyisici esiyinhloko esiholela ekwakhekeni kwe-pigmentation. Ama-endothelin antagonists angavimbela i-endothelin.. i-tyrosinase futhi akhuthaze ukuhlukaniswa kwama-melanocyte.

Ucwaningo luthole ukuthi abaphikisi be-endothelin abakhishwe ezintweni eziphila emanzini bane-cytotoxicity ephansi futhi bangavimbela ukuhlukaniswa kwe-endothelin kuma-melanocytes kanye nomsebenzi we-tyrosinase. Izifo ze-Skin hyperpigmentation ezibangelwa ukwanda -l zingase zibe namathemba okufaka isicelo.

2. I-Resveratrol kanye nokuphuma kwayo

I-Resveratrolikakhulukazi etholakala kumagilebhisi, i-Polygonum cuspidatum, i-Veratrum nezinye izitshalo, futhi ivimbela umsebenzi wama-melanocyte kanye nomsebenzi we-tyrosinase ngendlela encike ekugxilweni, ngaleyo ndlela yehlise ukuhlanganiswa kwe-melanin. UJeong et al uthole ukuthi kuhlotshaniswa namaprotheni ahlobene ne-tyrosinase ku-melanogenesis.

U-Jia Lili kanye nolunye ucwaningo luye lwabonisa ukuthi i-topical resveratrol ingathuthukisa ngempumelelo umbala wesikhumba, ibe nomthelela othile omhlophe, futhi ayinakho ukusabela okubi. I-Resveratrol inobubi bokungazinzi kanye ne-bioavailability embi. Ucwaningo luthole ukuthi okuphuma kuyo (okuphuma kwe-pentaalkyl ether kanye nokuphuma kwe-tetraester) kunokutholakala okuphezulu kwe-bioavailability futhi kungavimbela kangcono ukuhlanganiswa kwe-melanin. Inamathemba abanzi wokusebenzisa izimonyo ezimhlophe.

3. I-Camellia Extract

I-Camellia luhlobo lwe-Camellia yomndeni wakwaCamellia. Nakamura et al. ithole ukuthi i-camellia flower bud extract ingavimbela ukukhiqizwa kwe-melanin futhi ikhuthaze ukuhlukaniswa kwe-fibroblast. U-Huang Xiaofeng kanye nolunye ucwaningo luye lwaphetha ngokuthi igatsha letiye le-Dianshan kanye neqabunga elikhishwe lingcono kune-arbutin mayelana nokwanda kwamaseli kanye nokuvinjelwa komsebenzi we-tyrosinase, futhi linezakhiwo ezingcono kune-arbutin. Iwuhlobo olusha lwe-ejenti emhlophe yesikhumba futhi inohlu olubanzi lwezinhlelo zokusebenza. ithemba.

I-MelaninSynthaseIisivimbeli

1. I-Arbutin

Kuyi-tyrosinase inhibitor ebalulekile, engavimbela umsebenzi we-tyrosinase, ivimbele ukuhlanganiswa kwe-dopa ne-dopaquinone, ngaleyo ndlela ivimbele ukukhiqizwa kwe-melanin, futhi inganciphisa kakhulu umbala obangelwa imisebe ye-ultraviolet, kodwa uzinzile Ukusebenza okungalungile, ngokunye okuthile. ukuzwela kwesithombe.

Ucwaningo luthole ukuthi i-arbutin ene-concentration ye-3% inezakhiwo ezinhle, i-cytotoxicity ephansi, ukucasuka kanye nokungezwani komzimba, futhi umkhawulo ongaphezulu wokugxila kwayo awukwazi ukudlula u-7%. Ukuhlushwa okuphezulu kwe-arbutin kuzoshintsha umbala wesikhumba esivamile. Isithako sayo esisebenzayo semvelo, i-glucopyranoside, sinamandla okuvimbela i-tyrosinase yomuntu kune-arbutin, futhi sithatha indawo ye-arbutin ngoba isebenza kakhulu futhi izinzile.

2. I-Licorice Extract

Izithako zayo ezisebenzayo ikakhulukazi i-liquiritin, i-isoliquiritin ne-licorice flavonoids. I-Liquiritin yenza i-melanin yesikhumba isatshalaliswe ngokulinganayo ngokuhlakaza i-melanin ehlanganisiwe, futhi ifinyelele umphumela wokuba mhlophe; umsebenzi oyinhloko we-licorice flavonoids ukuvimbela umsebenzi we-tyrosinase, i-DHICA oxidase ne-dopa pigment intermutase.

Ucwaningo luye lwathola ukuthi imikhiqizo yokunakekelwa kwesikhumba yezokwelapha equkethe i-licorice ekhishwe kanye ne-papain ingasiza i-melasma kanye ne-hyperpigmentation yangemuva kokuvuvukala, nokusabela okuncane okubi, futhi ibe nezindawo ezithile .. kanye ... Ukugxila kwayo emikhiqizweni emhlophe kungu-10% kuya ku-40%, kodwa okuqukethwe kwezithako ezisebenzayo ku-licorice akuphakeme futhi ukuhlanzwa kunzima futhi kuyabiza.

3. I-Chuanxiong Extract

Ucwaningo luye lwathola ukuthi ukukhishwa kwe-Chuanxiong kungavimbela ngokuphumelelayo umsebenzi we-tyrosinase, okubonisa umphumela wokuncintisana wokuvimbela. Amafutha e-Chuanqiong athuthukiswe ngefomula eyinhlanganisela yama-emulsifiers ahlukene kanye nokujiya okuhlukene, ucwaningo mayelana nokusebenza kahle kwawo kokwenza mhlophe nokusebenza kwawo lubonise ukuthi amafutha e-Chuanqiong angu-0.5% ~ 1.0% anezici zokuzinza okuhle, ukusebenza okuphezulu nomphumela omuhle wokuba mhlophe .

4. I-Rhodiola Rosea Extract

I-salidroside kanye ne-flavonoid yizici zayo eziyinhloko ezisebenzayo, futhi i-salidroside ingalimaza i-lipids nolwelwesi lwamaseli ngemisebe ye-ultraviolet. I-extract ingavimbela ukuhlanganiswa kwe-melanin kanye nomsebenzi we-tyrosinase, futhi iyi-ejenti ephumelelayo yokumhlophe kwesikhumba. Ucwaningo luthole ukuthi i-1% kanye ne-5% ye-Rhodiola rosea ekhishwe ayizange ibangele ukusabela okubi emzimbeni womuntu, futhi iyisithako esisebenzayo sezimonyo esinokuzinza okuphezulu futhi sinethuba elibanzi ekusetshenzisweni kwezimonyo.

5. Aloin

Isitshalo esinesisindo esiphansi se-glycoprotein ekhishwe kunhlaba. Ivimbela ikakhulukazi ukwakheka kwe-dopaquinone ngokuncintisana ngokuvimbela indawo ye-dopa oxidation, futhi ifinyelela ukuvimbela okungekona ukuncintisana ngokuvimbela ama-ion ethusi ngokuncintisana endaweni ye-hydroxylase. Umsebenzi we-tyrosine hydroxylase. Ngaphezu kwalokho, i-aloin inganciphisa nokuba mnyama kwesikhumba okubangelwa imisebe ye-ultraviolet, futhi inomphumela omuhle wokulungisa esikhumbeni ngemva kokuchayeka elangeni. I-Aloin iyi-hydrophilic futhi ayiyona i-cytotoxic. Ukuxuba i-aloin ne-arbutin kungathuthukisa umphumela wokuba mhlophe.

6. Izitshalo ze-Polyphenols

Itholakala kakhulu emagxolweni, izimpande, amaqabunga nezithelo zezitshalo, futhi umphumela wayo wokuba mhlophe uhlobene kakhulu nokumuncwa kwemisebe ye-ultraviolet, ukuqedwa kwe-antioxidant yama-radicals mahhala, kanye nokuvinjwa kwe-tyrosinase nemisebenzi ye-peroxidase. I-Ellagic acid iyi-polyphenol yemvelo ekhishwe emakhasini ehalananda, amagxolo nezithelo nemifino ehlukahlukene. Ingavimbela ukwanda kwama-melanocyte, ivimbele umsebenzi we-melanocyte tyrosinase, inciphise ukwakheka kwe-melanin, imisebe ye-Ultraviolet inomphumela oqinile wokumuncwa, ongadlala indima ekuvikelweni kwelanga noma ekukhipheni ama-radicals mahhala ngokumunca imisebe ye-ultraviolet. I-polyphenol yezitshalo iwuhlobo lwesithako esisebenzayo, esinamathemba abanzi okuthuthukiswa nokusetshenziswa kwezimonyo.

Imininingwane yokuxhumana:
Le nkampani Shaanxi Ruiwo Phytochem Co., Ltd.
Umphathi Waphesheya: Jason
Isixuku: 0086-18629669868
I-imeyili:jason@ruiwophytochem.com
WhatsApp: 008618629669868