1. Abaphikisi be-Endothelin

Ikhishwe ku-chamomile yaseYurophu yemifino, engamelana ne-endothelin futhi ivimbele ukukhiqizwa kwama-melanocyte. Ukusatshalaliswa okungalingani kwe-endothelin esikhumbeni kuyisici esiyinhloko esiholela ekwakhekeni kombala. Abaphikisi be-Endothelin bangavimbela i-endothelin..tyrosinase futhi bakhuthaze ukuhlukaniswa kwama-melanocyte.

Izifundo zithole ukuthi izitha ze-endothelin ezikhishwe ezintweni eziphilayo zasemanzini zinobuthi obuphansi futhi zingavimbela ukuhlukaniswa kwe-endothelin kuma-melanocyte kanye nomsebenzi we-tyrosinase. Izifo zesikhumba ezibangelwa ukwanda kwe--l zingase zibe namathuba okusetshenziswa.

2. I-Resveratrol kanye nezinto eziphuma kuyo

I-ResveratrolItholakala kakhulu kumagilebhisi, i-Polygonum cuspidatum, i-Veratrum nezinye izitshalo, futhi ivimbela umsebenzi wama-melanocyte kanye nomsebenzi we-tyrosinase ngendlela encike ekugxilweni, ngaleyo ndlela inciphise ukwakheka kwe-melanin. UJeong nabanye bathole ukuthi ihlotshaniswa namaprotheni ahlobene ne-tyrosinase ekukhuleni kwe-melanin.

UJia Lili kanye nezinye izifundo zikhombisile ukuthi i-resveratrol yasendaweni ingathuthukisa umbala wesikhumba ngempumelelo, inomphumela othile wokwenza mhlophe, futhi ayinazo izimpendulo ezimbi. I-Resveratrol inezinkinga zokungazinzi kanye nokutholakala kabi kwe-bioavailability. Izifundo zithole ukuthi izithako zayo (i-pentaalkyl ether derivatives kanye ne-tetraester derivatives) zinokutholakala okuphezulu kwe-bioavailability futhi ingavimbela kangcono ukwakheka kwe-melanin. Inamathuba amaningi okusetshenziswa ezimonyweni zokwenza mhlophe.

3. I-Camellia Extract

I-Camellia uhlobo lwe-Camellia lomndeni wakwa-Camellia. UNakamura nabanye bathole ukuthi i-camellia flower bud extract ingavimbela ukukhiqizwa kwe-melanin futhi ikhuthaze ukuhlukaniswa kwe-fibroblast. U-Huang Xiaofeng kanye nezinye izifundo baphethe ngokuthi i-Dianshan tea branch kanye ne-leaf extract ingcono kune-arbutin maqondana nokwanda kwamaseli kanye nokuvimbela umsebenzi we-tyrosinase, futhi inezakhiwo ezingcono kune-arbutin. Luhlobo olusha lwe-ejenti yokwenza mhlophe isikhumba futhi lunezinhlelo zokusebenza eziningi.

I-MelaninSi-ynthaseIisithibithi

1. I-Arbutin

Kuyisivimbeli esibalulekile se-tyrosinase, esingavimbela umsebenzi we-tyrosinase, sivimbele ukwakheka kwe-dopa ne-dopaquinone, ngaleyo ndlela sivimbele ukukhiqizwa kwe-melanin, futhi singanciphisa kakhulu ukwakheka kombala okubangelwa imisebe ye-ultraviolet, kodwa sizinzile. Ukusebenza kabi, kanye nokuzwela okuthile kwe-photosensitivity.

Ucwaningo luthole ukuthi i-arbutin enezinga lika-3% inezakhiwo ezinhle, ubuthi obuphansi, ukucasuka kanye nokungezwani komzimba, futhi umkhawulo ophezulu wokuhlushwa kwayo awukwazi ukudlula u-7%. Izinga eliphezulu le-arbutin lizoshintsha umbala wesikhumba esivamile. Isithako sayo esisebenzayo semvelo, i-glucopyranoside, sinomphumela oqinile wokuvimbela i-tyrosinase yomuntu kune-arbutin, futhi sithatha indawo ye-arbutin ngoba isebenza kahle futhi izinzile.

2. I-Licorice Extract

Izithako zayo ezisebenzayo ikakhulukazi yi-liquiritin, i-isoliquiritin kanye ne-licorice flavonoids. I-Liquiritin yenza i-melanin yesikhumba isabalaliswe ngokulinganayo ngokusabalalisa i-melanin ehlanganisiwe, futhi ifinyelele umphumela wokuba mhlophe; umsebenzi oyinhloko we-licorice flavonoids ukuvimbela umsebenzi we-tyrosinase, i-DHICA oxidase kanye ne-dopa pigment intermutase.

Izifundo zithole ukuthi imikhiqizo yokunakekelwa kwesikhumba yezokwelapha equkethe i-licorice extract kanye ne-papain ingasiza i-melasma kanye ne-hyperpigmentation yangemva kokuvuvukala, ngemiphumela emibi embalwa, futhi inezimpawu ezithile .. kanye .. .. zokuhlushwa kwayo emikhiqizweni yokwenza mhlophe ingu-10% kuya ku-40%, kodwa okuqukethwe kwezithako ezisebenzayo ku-licorice akuphezulu futhi ukuhlanzwa kwayo kunzima futhi kuyabiza.

3. I-Chuanxiong Extract

Izifundo zithole ukuthi i-Chuanxiong extract ingavimbela ngempumelelo umsebenzi we-tyrosinase, ikhombisa umphumela wokuncintisana wokuvimbela. Amafutha e-Chuanqiong athuthukiswe ngefomula ehlanganisiwe yama-emulsifiers ahlukene kanye nama-thickeners ahlukene, ucwaningo ngokusebenza kwawo kokuba mhlophe lubonise ukuthi amafutha e-Chuanqiong angu-0.5% ~ 1.0% anezici zokuzinza okuhle, ukusebenza okuphezulu kanye nomphumela omuhle wokuba mhlophe.

4. I-Rhodiola Rosea Extract

I-Salidroside nama-flavonoid yizona zinto eziyinhloko ezisebenzayo, kanti i-salidroside ingalimaza ama-lipid kanye nama-membrane eseli ngemisebe ye-ultraviolet. I-extract ingavimbela ukwakheka kwe-melanin kanye nomsebenzi we-tyrosinase, futhi iyi-ejenti ephumelelayo yokwenza mhlophe isikhumba. Ucwaningo luthole ukuthi i-1% kanye ne-5% ye-Rhodiola rosea extract ayizange ibangele ukusabela okubi emzimbeni womuntu, futhi iyisithako esisebenzayo sezimonyo esinokuqina okuphezulu futhi sinethuba elibanzi ekusetshenzisweni kwezimonyo.

5. U-Aloin

Kuyi-glycoprotein yesitshalo esinesisindo esincane esikhishwe ku-aloe vera. Ivimbela kakhulu ukwakheka kwe-dopaquinone ngokuvimbela ngokuncintisana indawo yokuxiliswa kwe-dopa, futhi ifinyelela ekuvinjelweni okungekhona okuncintisana ngokuvimbela ngokuncintisana ama-ion ethusi endaweni ye-hydroxylase. Umsebenzi we-tyrosine hydroxylase. Ngaphezu kwalokho, i-aloin inganciphisa nokuba mnyama kwesikhumba okubangelwa imisebe ye-ultraviolet, futhi inomphumela omuhle wokulungisa esikhumbeni ngemva kokuchayeka elangeni. I-Aloin i-hydrophilic futhi ayinayo i-cytotoxic. Ukuxuba i-aloin ne-arbutin kungathuthukisa umphumela wokuba mhlophe.

6. Ama-Polyphenol Ezitshalo

Itholakala kakhulu emagxolweni, ezimpandeni, emaqabunga nasezithelweni zezitshalo, futhi umphumela wayo wokuba mhlophe uhlobene kakhulu nokumuncwa kwayo imisebe ye-ultraviolet, ukususwa kwama-free radicals alwa ne-antioxidant, kanye nokuvimbela imisebenzi ye-tyrosinase kanye ne-peroxidase. I-Ellagic acid iyi-polyphenol yemvelo ekhishwe emakhasini e-pomegranate, emagxolweni kanye nezithelo nemifino ehlukahlukene. Ingavimbela ukwanda kwama-melanocyte, ivimbele umsebenzi we-melanocyte tyrosinase, inciphise ukwakheka kwe-melanin, imisebe ye-Ultraviolet inomphumela oqinile wokumuncwa, ongadlala indima ekuvikelweni kwelanga noma ekususeni ama-free radicals ngokumuncwa kwemisebe ye-ultraviolet. I-Plant polyphenol uhlobo lwesithako esisebenzayo, esinamathuba abanzi okuthuthukiswa nokusetshenziswa kwezimonyo.

Imininingwane yokuxhumana:
Le nkampani Shaanxi Ruiwo Phytochem Co., Ltd.
Umphathi Waphesheya: UJason
I-Mob: 0086-18629669868
I-imeyili:jason@ruiwophytochem.com
I-Whatsapp: 008618629669868