Iyini i-Shikimic Acid?

I-Shikimic acid (3,4,5-trihydroxy-1-cyclohexene-1-carboxylic acid) iyinhlanganisela eyenzeka ngokwemvelo eyingxenye ebalulekile ye-biosynthesis ye-lignin, ama-amino acid anephunga elimnandi (phenylalanine, tyrosine ne-tryptophan), kanye neningi. isitshalo kanye ne-microbial alkaloids.

I-Shikimic acid ijwayele ukusetshenziswa njengesiqalo sokuhlanganiswa kwezimboni zomuthi ovimbela amagciwane i-oseltamivir (umuthi olwa ne-H5N1 wegciwane lomkhuhlane osetshenziselwa ukwelapha nokuvimbela zonke izinhlobo ezaziwayo zamagciwane omkhuhlane). I-synthesis ye-(-)-zeylenone esekelwe ku-Shikimic Acid kubikwe ukuthi isetshenziswa kabanzi njenge-ejenti yokwelapha ngamakhemikhali omdlavuza. Idatha iyatholakala ekuhlanganiseni kwe-monopalmitoyloxy Shikimic Acid, enomsebenzi we-anticoagulant futhi ekwazi ukwehlisa i-coagulability yegazi lapho ilawulwa nge-intramuscularly. Ithimba labacwaningi baseShayina lihlanganise okuphuma ku-Shikimic Acid, i-triacetyl Shikimic Acid, ebonisa umsebenzi we-anticoagulant kanye ne-antithrombotic.

Ngaphezu kwalokho, izinto eziphuma ku-Shikimic Acid zibonise isithakazelo esikhulu kwezolimo njengoba eziningi zazo zisetshenziswa njengama-herbicides nama-antimicrobial agents ngoba zingavimba indlela ye-Shikimic Acid ezitshalweni namagciwane ngaphandle kokuphazamisa kabi izilwane ezincelisayo.

Ngakho-ke, i-Shikimic Acid ingasetshenziswa njenge-reactant for organic synthesis kokubili isayensi eyisisekelo kanye nezicelo zezokwelapha kumakhemikhali wezinto eziphilayo kanye nemithi, ikakhulukazi ukulungiswa kwezidakamizwa ezihlukahlukene.

Njengengxenye ebalulekile yekhemikhali yemithi, i-shikimic acid ingasetshenziswa ekwelapheni izifo eziningi:

1. I-antibacterial kanye ne-antitumor

Ngo-1987, izazi zaseJapane zathola ukuthi i-analog ye-glyoxalase I inhibitor ehlanganiswe yi-methyl anthranilate inomphumela osobala wokuvimbela ku-Hela cell line kanye ne-Escheri ascites carcinoma, ingandisa isikhathi sokusinda samagundane afakwe i-leukemia cell L1210, futhi ubuthi buphansi kakhulu. umphumela wawo ovimbelayo uhlobene ikakhulukazi nokusabela kwesulfure hydride. Ngo-1988, izazi zaseShayina ziye zahlanganisa i-shikimic acid derivative futhi zafakazela ukuthi le nhlanganisela inomphumela wokuvimbela amaseli we-leukemia L1210 in vitro.

2. I-Anti-thrombosis

Umthelela we-shikimic acid kanye nokuphuma kwawo ohlelweni lwenhliziyo uboniswa endimeni ye-anti-thrombosis kanye nokuvinjelwa kokuhlangana kweplatelet. Ucwaningo lubonisa ukuthi: i-shikimic acid inomphumela oqinile wokuvimbela i-platelet aggregation rate ye-adenosine diphosphate-induced middle cerebral artery embolism model amagundane; umjovo ofakwa emthanjeni kanye ne-intramuscular we-shikimic acid ungenza isikhathi sokujiya kwegazi samagundane sibe side.

3.Anti-cerebral ischemia

I-Shikimic acid kanye nokuphuma kwayo kunomphumela wokuthuthukisa i-cerebral ischemia, ikakhulukazi ekwehliseni umthamo we-cerebral infarction ngemuva kokugxila kwe-cerebral ischemia kumagundane, ukunciphisa umsebenzi wezinzwa, ukunciphisa izinga le-cerebral edema, okwandisa ukugeleza kwegazi ku-cerebral endaweni ye-ischemic. nezinye izinkomba. Olunye ucwaningo luye lwabonisa ukuthi okuphuma kulo kunganciphisa izinga le-erythrocyte aggregation futhi kuvimbele ukuhlangana kweplatelet ngemva kwe-cerebral ischemia, ngaleyo ndlela kube lula ukujikeleza kwe-cerebral microcirculation.