Kuyini i-Shikimic Acid?

I-Shikimic acid (3,4,5-trihydroxy-1-cyclohexene-1-carboxylic acid) iyinhlanganisela yemvelo eyenzeka ngokwemvelo eyingxenye ebalulekile ekuhlanganisweni kwe-lignin, ama-amino acid anuka kamnandi (i-phenylalanine, i-tyrosine kanye ne-tryptophan), kanye nama-alkaloid amaningi ezitshalo namagciwane.

I-Shikimic acid ivame ukusetshenziswa njengento yokuqala yokwenziwa kwezimboni komuthi wokulwa namagciwane i-oseltamivir (umuthi wegciwane lomkhuhlane i-H5N1 osetshenziselwa ukwelapha nokuvimbela zonke izinhlobo ezaziwayo zamagciwane omkhuhlane). Ukwenziwa kwe-(-)-zeylenone okusekelwe ku-Shikimic Acid kubikwe ukuthi kusetshenziswa kabanzi njenge-ejenti ye-chemotherapy yomdlavuza. Imininingwane iyatholakala ngokwenziwa kwe-monopalmitoyloxy Shikimic Acid, enomsebenzi we-anticoagulant futhi ekwazi ukunciphisa ukujiya kwegazi uma inikezwa nge-intramuscularly. Ithimba locwaningo laseShayina lenze i-Shikimic Acid derivative, i-triacetyl Shikimic Acid, ekhombisa umsebenzi we-anticoagulant kanye ne-antithrombotic.

Ngaphezu kwalokho, izinto ezisuselwa ku-Shikimic Acid zibonise intshisekelo enkulu kwezolimo njengoba eziningi zazo zisetshenziswa njengemithi yokubulala ukhula kanye nama-antimicrobial agents ngoba zingavimba indlela ye-Shikimic Acid ezitshalweni kanye namagciwane ngaphandle kokuthinta kabi izilwane ezincelisayo.

Ngakho-ke, i-Shikimic Acid ingasetshenziswa njenge-reactant yokwenziwa kwezinto eziphilayo kokubili kwisayensi eyisisekelo kanye nezicelo zezokwelapha kumakhemikhali ezinto eziphilayo kanye nemithi, ikakhulukazi ekulungiseleleni izidakamizwa ezahlukahlukene.

Njengezinto ezibalulekile zamakhemikhali emithi, i-shikimic acid ingasetshenziswa ekwelapheni izifo eziningi:

1. Ilwa namagciwane kanye nomdlavuza

Ngo-1987, izazi zaseJapane zathola ukuthi i-analog ye-glyoxalase I inhibitor eyenziwe yi-methyl anthranilate inomphumela ocacile wokuvimbela ku-Hela cell line kanye ne-Escheri ascites carcinoma, ingandisa isikhathi sokusinda kwamagundane afakwe i-leukemia cell L1210, futhi ubuthi buphansi kakhulu, umphumela wayo wokuvimbela uhlobene kakhulu nokusabela kwe-sulfur hydride. Ngo-1988, izazi zaseShayina zathola Ngo-1988, izazi zaseShayina zakhiqiza i-shikimic acid derivative futhi zafakazela ukuthi le nhlanganisela inomphumela wokuvimbela amaseli e-leukemia L1210 ku-vitro.

2. I-Anti-thrombosis

Umphumela we-shikimic acid kanye nezinto eziphuma kuyo ohlelweni lwezinhliziyo ubonakala endimeni yokulwa ne-thrombosis kanye nokuvinjelwa kokuhlanganiswa kwama-platelet. Ucwaningo lubonisa ukuthi: i-shikimic acid inomphumela oqinile wokuvimbela izinga lokuhlanganiswa kwama-platelet lamagundane asebenzisa i-adenosine diphosphate-induced middle cerebral artery embolism; ukujova ngemithambo yegazi kanye nemisipha kwe-shikimic acid kungenza isikhathi sokujiya kwegazi samagundane sikhule.

3. I-Anti-cerebral ischemia

I-Shikimic acid kanye ne-derivatives yayo inomphumela wokuthuthukisa i-cerebral ischemia, ikakhulukazi ekunciphiseni ivolumu ye-cerebral infarction ngemuva kwe-focal cerebral ischemia kumagundane, ukunciphisa amaphuzu okusebenza kwezinzwa, ukunciphisa izinga le-cerebral edema, ukwandisa ukugeleza kwegazi lobuchopho endaweni ye-ischemic kanye nezinye izinkomba. Ezinye izifundo zibonise ukuthi i-derivatives yayo inganciphisa izinga lokuhlangana kwe-erythrocyte futhi ivimbele ukuhlangana kwe-platelet ngemuva kwe-cerebral ischemia, ngaleyo ndlela kube lula ukujikeleza kwegazi ebuchosheni.